Treatment of candida esophagitis in AIDS patients

• Published in: The American journal of gastroenterology Vol. 83; no. 1; p. 20
• Main Authors: Deschamps, M M, Pape, J W, Verdier, R I, DeHovitz, J, Thomas, F, Johnson, Jr, W D
• Format: Journal Article
• Language: English
• Published: United States 01.01.1988
• Subjects: Acquired Immunodeficiency Syndrome - complications; Administration, Oral; Adult; Candidiasis - drug therapy; Candidiasis - etiology; Clinical Trials as Topic; Esophageal Diseases - drug therapy; Esophageal Diseases - etiology; Humans; Ketoconazole - administration & dosage; Ketoconazole - adverse effects; Ketoconazole - therapeutic use; Miconazole - administration & dosage; Miconazole - adverse effects; Miconazole - therapeutic use; Prospective Studies; Random Allocation
• DOI: 10.1111/j.1572-0241.1988.tb01801.x
• ISSN: 0002-9270

We conducted a randomized prospective study to compare the efficacy of oral miconazole and ketoconazole in the treatment of candida esophagitis in acquired immune deficiency syndrome (AIDS) patients in Haiti. Twelve AIDS patients with endoscopic and microscopic diagnoses of candida esophagitis were placed on either oral miconazole or ketoconazole for 10 days. All six patients receiving oral miconazole, and four of the six receiving ketoconazole had complete resolution of their esophageal lesions at the end of treatment. We conclude oral miconazole is at least as effective as ketoconazole in the treatment of candida esophagitis in AIDS patients.