The BASILICA Trial: Prospective Multicenter Investigation of Intentional Leaflet Laceration to Prevent TAVR Coronary Obstruction

• Published in: JACC. Cardiovascular interventions Vol. 12; no. 13; pp. 1240 - 1252
• Main Authors: Khan, Jaffar M, Greenbaum, Adam B, Babaliaros, Vasilis C, Rogers, Toby, Eng, Marvin H, Paone, Gaetano, Leshnower, Bradley G, Reisman, Mark, Satler, Lowell, Waksman, Ron, Chen, Marcus Y, Stine, Annette M, Tian, Xin, Dvir, Danny, Lederman, Robert J
• Format: Journal Article
• Language: English
• Published: United States 08.07.2019
• Subjects: Aged; Aged, 80 and over; Aortic Valve - diagnostic imaging; Aortic Valve - physiopathology; Aortic Valve - surgery; Aortic Valve Stenosis - diagnostic imaging; Aortic Valve Stenosis - physiopathology; Aortic Valve Stenosis - surgery; Bioprosthesis; Coronary Stenosis - diagnostic imaging; Coronary Stenosis - etiology; Coronary Stenosis - physiopathology; Coronary Stenosis - prevention & control; Feasibility Studies; Female; Heart Valve Prosthesis; Heart Valve Prosthesis Implantation - adverse effects; Heart Valve Prosthesis Implantation - instrumentation; Hemodynamics; Humans; Iatrogenic Disease - prevention & control; Male; Prospective Studies; Prosthesis Design; Prosthesis Failure; Risk Factors; Time Factors; Transcatheter Aortic Valve Replacement - adverse effects; Transcatheter Aortic Valve Replacement - instrumentation; Treatment Outcome; United States; United States; coronary artery obstruction; transcatheter aortic valve replacement; transcatheter electrosurgery; bioprosthetic heart valve failure; structural heart disease

The BASILICA (Bioprosthetic or native Aortic Scallop Intentional Laceration to prevent Iatrogenic Coronary Artery obstruction during TAVR) investigational device exemption trial was a prospective, multicenter, single-arm safety and feasibility study. Coronary artery obstruction is a rare but devasta...