Superoxide Dismutase (SOD)-mimetic M40403 Is Protective in Cell and Fly Models of Paraquat Toxicity: IMPLICATIONS FOR PARKINSON DISEASE

• Published in: The Journal of biological chemistry Vol. 291; no. 17; pp. 9257 - 9267
• Main Authors: Filograna, Roberta, Godena, Vinay K, Sanchez-Martinez, Alvaro, Ferrari, Emanuele, Casella, Luigi, Beltramini, Mariano, Bubacco, Luigi, Whitworth, Alexander J, Bisaglia, Marco
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 22.04.2016
• Subjects: Animals; Biomimetic Materials - pharmacology; Cell Line, Tumor; Drosophila melanogaster; Humans; Manganese - pharmacology; Models, Biological; Molecular Bases of Disease; Organometallic Compounds - pharmacology; Oxidative Stress - drug effects; Paraquat - adverse effects; Paraquat - pharmacology; Parkinson Disease - drug therapy; Parkinson Disease - metabolism; Superoxide Dismutase; Parkinson disease; superoxide ion; antioxidant; superoxide dismutase (SOD); oxidative stress

Parkinson disease is a debilitating and incurable neurodegenerative disorder affecting ∼1-2% of people over 65 years of age. Oxidative damage is considered to play a central role in the progression of Parkinson disease and strong evidence links chronic exposure to the pesticide paraquat with the inc...