Deciphering pharmacokinetics and pharmacodynamics of fosfomycin

• Published in: Revista española de quimioterapia Vol. 32 Suppl 1; no. Suppl 1; pp. 19 - 24
• Main Authors: Rodríguez-Gascón, A, Canut-Blasco, A
• Format: Journal Article
• Language: English
• Published: Spain Sociedad Española de Quimioterapia 01.05.2019
• Subjects: Animals; Anti-Bacterial Agents - pharmacokinetics; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Bacterial Infections - drug therapy; Bacterial Infections - microbiology; Current Key Topics in Fosfomycin; Fosfomycin - pharmacokinetics; Fosfomycin - pharmacology; Fosfomycin - therapeutic use; Humans

Fosfomycin, a low molecular weight and hydrophilic drug with negligible protein binding, is eliminated almost exclusively by glomerular filtration, whose clearance is subject to patient renal function. The volume of distribution approximates to the extracellular body water (about 0.3 L/Kg) in health...