Polysaccharide conjugate vaccine responses in bone marrow transplant patients

• Published in: Transplantation Vol. 57; no. 5; p. 677
• Main Authors: Guinan, E C, Molrine, D C, Antin, J H, Lee, M C, Weinstein, H J, Sallan, S E, Parsons, S K, Wheeler, C, Gross, W, McGarigle, C
• Format: Journal Article
• Language: English
• Published: United States 15.03.1994
• Subjects: Adolescent; Adult; Aging - blood; Antibody Formation; Bacterial Proteins - immunology; Bone Marrow Transplantation - immunology; Child; Child, Preschool; Haemophilus Vaccines - immunology; Humans; Immunization; Immunoglobulin A - blood; Immunoglobulin G - blood; Immunoglobulin M - blood; Infant; Middle Aged; Tetanus Toxoid - immunology; Time Factors; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - immunology

Bone marrow transplant patients have impaired responses to pure polysaccharide (PS) vaccines and are at an increased risk for disease caused by PS encapsulated pathogens such as Haemophilus influenzae type B (HIB) and Streptococcus pneumoniae. We immunized 35 BMT patients (21 allogeneic and 14 autol...