Role of Bcl-2 and its associated miRNAs in vasculogenic mimicry of hepatocellular carcinoma

• Published in: International journal of clinical and experimental pathology Vol. 8; no. 12; pp. 15759 - 15768
• Main Authors: Zhao, Nan, Sun, Bao-Cun, Zhao, Xiu-Lan, Wang, Yong, Meng, Jie, Che, Na, Dong, Xu-Yi, Gu, Qiang
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 01.01.2015
• Subjects: Carcinoma, Hepatocellular - blood supply; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit - genetics; Hypoxia-Inducible Factor 1, alpha Subunit - metabolism; Liver Neoplasms - blood supply; Liver Neoplasms - genetics; Liver Neoplasms - metabolism; Liver Neoplasms - pathology; MicroRNAs - genetics; MicroRNAs - metabolism; Molecular Mimicry; Neovascularization, Pathologic; Original; Prognosis; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; Signal Transduction; Transfection; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; Bcl-2; miRNA; vasculogenic mimicry; HIF1A; VEGF; hepatocellular carcinoma

An investigation of the role of the anti-apoptotic protein Bcl-2 and its associated miRNAs in vasculogenic mimicry (VM) in hepatocellular carcinoma. The Bcl-2 expression plasmid was constructed for transfection into the hepatocellular carcinoma cell line HepG2. Changes in the expression profiles of...