Circadian protein CLK suppresses transforming growth factor-β expression in peripheral B cells of nurses with day-night shift rotation

• Published in: American journal of translational research Vol. 10; no. 12; pp. 4331 - 4337
• Main Authors: Yang, Hui, Yang, Li-Tao, Liu, Jun, Tang, Shan, Zhao, Xiulan, Wang, Qiaohong, Zhang, Shaoguo, Shi, Meixia, Pan, Wei, Yang, Ping-Chang
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 01.01.2018
• Subjects: Original; B lymphocyte; nurse; nuclear factor-interleukin-3; circadian CLK; interleukin-10
• ISSN: 1943-8141; 1943-8141

The mechanism of dysfunction of regulatory B cells is unclear. The circadian locomotor output cycles kaput (CLK) regulates immune responses. CLK expression can be increased by alteration of the circadian rhythm. This study tests a hypothesis that alteration of the circadian rhythm, such as engaging...