The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis

• Published in: Nature genetics Vol. 18; no. 3; pp. 257 - 261
• Main Authors: ODORISIO, T, RODRIGUEZ, T. A, EVANS, E. P, CLARKE, A. R, BURGOYNE, P. S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group 01.03.1998
• Subjects: Animals; Apoptosis - genetics; Apoptosis - radiation effects; Biological and medical sciences; Chromosome Aberrations; Cytogenetics; DNA Damage - genetics; DNA Damage - radiation effects; Female; Fundamental and applied biological sciences. Psychology; Genes, p53; Genetics of eukaryotes. Biological and molecular evolution; Male; Meiosis; Mice; Mice, Inbred Strains; Models, Biological; Spermatocytes - physiology; Synaptonemal Complex - genetics; Testis - pathology; Testis - radiation effects; Vertebrata; Whole-Body Irradiation; X Chromosome; Y Chromosome; Chromosome pairing; Spermatogenesis; p53 Protein; Rodentia; Sex chromosome; Meiosis; Germinal cell; Double strand break; Vertebrata; Mammalia; Spermatocyte; Mouse; Cytogenetics; Apoptosis

Evidence is accumulating that meiosis is subject to 'checkpoints' that monitor the quality of this complex process. In yeast, unresolved double strand breaks (DSBs) in DNA are thought to trigger a 'recombination checkpoint' that leads to pachytene arrest. In higher eukaryotes, th...