Alterations of retinal vasculature in cystathionine-β-synthase heterozygous mice: a model of mild to moderate hyperhomocysteinemia

• Published in: The American journal of pathology Vol. 184; no. 9; pp. 2573 - 2585
• Main Authors: Tawfik, Amany, Markand, Shanu, Al-Shabrawey, Mohamed, Mayo, Jamie N, Reynolds, Jason, Bearden, Shawn E, Ganapathy, Vadivel, Smith, Sylvia B
• Format: Journal Article
• Language: English
• Published: United States American Society for Investigative Pathology 01.09.2014
• Subjects: Animals; Cystathionine beta-Synthase - genetics; Disease Models, Animal; Heterozygote; Hyperhomocysteinemia - genetics; Hyperhomocysteinemia - pathology; Mice; Mice, Mutant Strains; Microscopy, Fluorescence; Real-Time Polymerase Chain Reaction; Regular; Retinal Neovascularization - genetics; Retinal Neovascularization - pathology; Retinal Vessels - pathology

Mild to moderate hyperhomocysteinemia is prevalent in humans and is implicated in neurovascular diseases, including recently in certain retinal diseases. Herein, we used hyperhomocysteinemic mice deficient in the Cbs gene encoding cystathionine-β-synthase (Cbs(+/-)) to evaluate retinal vascular inte...