Endotoxin and pro-inflammatory cytokines stimulate endothelin-1 expression and release by airway epithelial cells

• Published in: Clinical and experimental allergy Vol. 24; no. 4; pp. 330 - 336
• Main Authors: NAKANO, J, TAKIZAWA, H, OHTOSHI, T, SHOJI, S, YAMAGUCHI, M, ISHII, A, YANAGISAWA, M, ITO, K
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.04.1994
• Subjects: Aged; Biological and medical sciences; Bronchi - drug effects; Bronchi - physiology; Cells, Cultured; Chronic obstructive pulmonary disease, asthma; Cycloheximide - pharmacology; Cytokines - pharmacology; Endothelins - biosynthesis; Endothelins - genetics; Endothelins - metabolism; Endotoxins - pharmacology; Epithelium - drug effects; Epithelium - physiology; Female; Gene Expression - drug effects; Humans; In Vitro Techniques; Inflammation - etiology; Inflammation - physiopathology; Interleukin-1 - pharmacology; Lipopolysaccharides - pharmacology; Male; Medical sciences; Middle Aged; Pneumology; RNA, Messenger - genetics; RNA, Messenger - metabolism; Tumor Necrosis Factor-alpha - pharmacology; Human; Respiratory disease; Pathogenesis; Cytokine; Bronchus; Endothelin 1; Gene expression; Endotoxin; In vitro; Asthma; Microbial origin; Tumor necrosis factor; Interleukin 1; Epithelial cell; Obstructive pulmonary disease; Release

Endothelin is a potent bronchoconstrictor peptide first identified as a novel vasoconstrictor produced by vascular endothelial cells. Recent reports suggest that airway epithelial cells are also capable of releasing this active peptide. To investigate the regulatory mechanism of endothelin expressio...