eNOS overexpression exacerbates vascular closure in the obliterative phase of OIR and increases angiogenic drive in the subsequent proliferative stage

• Published in: Investigative ophthalmology & visual science Vol. 53; no. 11; pp. 6833 - 6850
• Main Authors: Edgar, Kevin, Gardiner, Thomas A, van Haperen, Rien, de Crom, Rini, McDonald, Denise M
• Format: Journal Article
• Language: English
• Published: United States The Association for Research in Vision and Ophthalmology 01.10.2012
• Subjects: Animals; Blotting, Western; Cell Proliferation; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Male; Mice; Mice, Inbred C57BL; Nitric Oxide Synthase Type III - biosynthesis; Retinal Neovascularization - enzymology; Retinal Neovascularization - pathology; Retinal Vessels - enzymology; Retinal Vessels - pathology

In ischemic retinopathies, the misdirection of reparative angiogenesis away from the hypoxic retina leads to pathologic neovascularization. Thus, therapeutic strategies that reverse this trend would be extremely beneficial. Nitric oxide (NO) produced by endothelial nitric oxide synthase (eNOS) is an...