Ropivacaine mesylate exerts neurotoxicity via up-regulation of Fas/FasL expression in rat pheochromocytoma PC12 cells

• Published in: American journal of translational research Vol. 11; no. 3; pp. 1626 - 1634
• Main Authors: Luo, Zhao, Zhang, Zhen, Zhang, Fuyu, Liu, Ying, Zhang, Yang, Sun, Xiaodong, Sang, Ming, Luo, Huiyu
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 01.01.2019
• Subjects: Original; Fas; apoptosis; Ropivacaine mesylate; FasL; PC12 cells

It has been shown that local anesthetics have potential neurotoxicity, but the exact mechanism remains unclear. In this study, PC12 cells were treated with different concentrations of ropivacaine mesylate (0.1, 0.5, 1, 2 and 4 mmol/L) for 24 h, the cell viability was assessed by CCK-8 assay. Then, c...