Electrochemically Mediated Synthesis of Cyanated Heterocycles from α‐amino Esters, Pyridine‐2‐carbaldehydes and NH4SCN as Cyano Group Source

• Published in: Chemistry : a European journal Vol. 31; no. 15; pp. e202404051 - n/a
• Main Authors: Grishin, Sergei S., Ustyuzhanin, Alexander O., Vil', Vera A., Terent'ev, Alexander O.
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 12.03.2025
• Subjects: 4-oxo-4H-pyrido pyrido[1,2-a]pyrazines; Anions; Anodizing; Aromatic compounds; Carboxylates; Chemical reactions; Chemical synthesis; cyanation; Cyanide process; Cyano groups; Electrochemical cells; Electrochemistry; Esters; Fungicidal activity; Fungicides; Glycine; imidazo[1,5-a]pyridines; Intermediates; Oxidation; Phytopathogenic fungi; Pyrazine; Pyrazines; Pyridines

The electrochemically mediated cyanation/annulation process with in situ cyanide ion generation from NH4SCN and multi‐step oxidative construction of CN‐functionalized heterocycles from easily available α‐amino esters and pyridine‐2‐carbaldehydes has been discovered. Depending on the nature of the α‐...