Iron-binding proteins and C-reactive protein in Nipple Aspirate Fluids: role of Iron-driven inflammation in breast cancer microenvironment?

• Published in: American journal of translational research Vol. 3; no. 1; pp. 100 - 113
• Main Authors: Mannello, Ferdinando, Tonti, Gaetana A, Simone, Patrizia, Ligi, Daniela, Medda, Virginia
• Format: Journal Article
• Language: English
• Published: United States e-Century Publishing Corporation 30.10.2010
• Subjects: Original; transferrin; iron; ferritin; Breast cancer; nipple aspirate fluid; inflammation

Breast cancer, a worldwide disease with increasing incidence, develops from ductal/lobular epithelium. Nipple aspirate fluid (NAF), secreted from the breast ducts and lobules, can be analyzed to assess metabolic activity in breast microenvironment. Premalignant and malignant cell alterations may pro...