Passive immunization with anti-Tau antibodies in two transgenic models: reduction of Tau pathology and delay of disease progression

• Published in: The Journal of biological chemistry Vol. 286; no. 39; pp. 34457 - 34467
• Main Authors: Chai, Xiyun, Wu, Su, Murray, Tracey K, Kinley, Robert, Cella, Claire V, Sims, Helen, Buckner, Nicola, Hanmer, Jenna, Davies, Peter, O'Neill, Michael J, Hutton, Michael L, Citron, Martin
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 30.09.2011
• Subjects: Alzheimer Disease - genetics; Alzheimer Disease - immunology; Alzheimer Disease - pathology; Alzheimer Disease - therapy; Amino Acid Substitution - immunology; Animals; Antibodies - immunology; Antibodies - pharmacology; Disease Models, Animal; Humans; Immunization, Passive - methods; Mice; Mice, Transgenic; Molecular Bases of Disease; Motor Activity - drug effects; Motor Activity - genetics; Motor Activity - immunology; Mutation, Missense - immunology; tau Proteins - genetics; tau Proteins - immunology

The microtubule-associated protein Tau plays a critical role in the pathogenesis of Alzheimer disease and several related disorders (tauopathies). In the disease Tau aggregates and becomes hyperphosphorylated forming paired helical and straight filaments, which can further condense into higher order...