Estrogen-mediated effects on cognition and synaptic plasticity: what do estrogen receptor knockout models tell us?

• Published in: Biochimica et biophysica acta Vol. 1800; no. 10; pp. 1090 - 1093
• Main Authors: Kim, Hyun Jin, Casadesus, Gemma
• Format: Journal Article
• Language: English
• Published: Netherlands 01.10.2010
• Subjects: Animals; Brain - cytology; Brain - metabolism; Cognition - physiology; Estrogen Receptor alpha - genetics; Estrogen Receptor alpha - metabolism; Estrogen Receptor beta - genetics; Estrogen Receptor beta - metabolism; Estrogens - metabolism; Female; Gene Expression Regulation - physiology; Humans; Male; Mice; Mice, Knockout; Neuroglia - cytology; Neuroglia - metabolism; Neuronal Plasticity - physiology; Neurons - cytology; Neurons - metabolism; Protein Multimerization - physiology; Synapses - genetics; Synapses - metabolism; Transcription, Genetic - physiology

A plethora of evidence supports a beneficial role of estrogen in the brain. However, while these effects are hypothesized to be driven via the two main forms of estrogen receptors (ERα and ERß), the mechanism through which these receptors mediate estrogen's effects on cognition and plasticity r...