A novel locus for Usher syndrome type I, USH1G, maps to chromosome 17q24-25

Usher syndrome (USH) is an autosomal recessive disorder associated with sensorineural hearing impairment and progressive visual loss attributable to retinitis pigmentosa. This syndrome is both clinically and genetically heterogeneous. Three clinical types have been described of which type I (USH1) i...

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Published inHuman genetics Vol. 110; no. 4; pp. 348 - 350
Main Authors MUSTAPHA, Mirna, CHOUERY, Eliane, WEIL, Dominique, TORCHARD-PAGNEZ, Delphine, NOUAILLE, Sylvie, KHRAIS, Awni, SAYEGH, Fouad N, MEGARBANE, André, LOISELET, Jacques, LATHROP, Mark, PETIT, Christine
Format Journal Article
LanguageEnglish
Published Heidelberg Springer 01.04.2002
Berlin Springer Nature B.V
New York, NY
Subjects
Adult
Biological and medical sciences
Chromosome Mapping
Chromosomes, Human, Pair 17
Female
Genetic Linkage
Hearing Loss, Sensorineural - genetics
Humans
Male
Medical sciences
Ophthalmology
Pedigree
Retinitis Pigmentosa - genetics
Retinopathies
Syndrome
Jordan
Asia
Genetic mapping
Human
Eye disease
Retinopathy
Linkage
Chromosome E17
Family study
Usher syndrome
Nutrition disorder
ENT disease
Genetic disease
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Summary:Usher syndrome (USH) is an autosomal recessive disorder associated with sensorineural hearing impairment and progressive visual loss attributable to retinitis pigmentosa. This syndrome is both clinically and genetically heterogeneous. Three clinical types have been described of which type I (USH1) is the most severe. Six USH1 loci have been identified. We report a Palestinian consanguineous family from Jordan with three affected children. In view of the combination of profound hearing loss, vestibular dysfunction, and retinitis pigmentosa in the patients, we classified the disease as USH1. Linkage analysis excluded the involvement of any of the known USH1 loci. A genome-wide screening allowed us to map this novel locus, USH1G, in a 23-cM interval on chromosome 17q24-25. The USH1G interval overlaps the intervals for two dominant forms of isolated hearing loss, namely DFNA20 and DFNA26. Since several examples have been reported of syndromic and isolated forms of deafness being allelic, USH1G, DFNA20, and DFNA26 might result from alterations of the same gene. Finally, a mouse mutant, jackson shaker ( js), with deafness and circling behavior has been mapped to the murine homologous region on chromosome 11.
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ISSN:0340-6717
1432-1203
DOI:10.1007/s00439-002-0690-x