Reduced cardiovascular morbidity and mortality in hypertensive diabetic patients on first-line therapy with an ACE inhibitor compared with a diuretic/ β-blocker-based treatment regimen: A subanalysis of the Captopril Prevention Project

• Published in: Diabetes care Vol. 24; no. 12; pp. 2091 - 2096
• Main Authors: NISKANEN, Leo, HEDNER, Thomas, HANSSON, Lennart, LANKE, Jan, NIKLASON, Anders
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.12.2001
• Subjects: Adrenergic beta-Antagonists - therapeutic use; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Biological and medical sciences; Blood Glucose - analysis; Body Mass Index; Captopril - therapeutic use; Cardiovascular disease; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - mortality; Cardiovascular Diseases - prevention & control; Cholesterol - blood; Cholesterol, HDL - blood; Diabetes; Diabetes Complications; Diabetic Angiopathies - drug therapy; Diuretics - therapeutic use; Drug therapy; Female; Humans; Hypertension; Hypertension - complications; Hypertension - drug therapy; Male; Medical sciences; Middle Aged; Morbidity; Mortality; Myocardial Infarction - epidemiology; Myocardial Infarction - mortality; Prospective Studies; Risk; Stroke - epidemiology; Stroke - mortality

The Captopril Prevention Project (CAPPP) evaluated the effects of an ACE inhibitor-based therapeutic regimen on cardiovascular mortality and morbidity in hypertension. One planned subanalysis of the CAPPP was to evaluate the outcome in the diabetic patient group. In the CAPPP, 572 (4.9% of 10,985 hy...