Reactive oxygen species delay control of lymphocytic choriomeningitis virus

• Published in: Cell death and differentiation Vol. 20; no. 4; pp. 649 - 658
• Main Authors: Lang, P A, Xu, H C, Grusdat, M, McIlwain, D R, Pandyra, A A, Harris, I S, Shaabani, N, Honke, N, Kumar Maney, S, Lang, E, Pozdeev, V I, Recher, M, Odermatt, B, Brenner, D, Häussinger, D, Ohashi, P S, Hengartner, H, Zinkernagel, R M, Mak, T W, Lang, K S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2013; Nature Publishing Group
• Subjects: 631/250/1933; 631/80/86; 692/699/255/2514; 692/700/139/422; Animals; Apoptosis; Biochemistry; Biomedical and Life Sciences; Breast cancer; Buthionine Sulfoximine - pharmacology; Cancer research; CD8 antigen; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; Cell Biology; Cell Cycle Analysis; Cell death; Cell Survival; Cells, Cultured; Chronic infection; Differentiation; Disease Models, Animal; Glutathione - metabolism; Granulocytes; Health care networks; Hepatitis C; Hepatocytes; Hospitals; Immune response; Immunology; Infections; Leukocytes (granulocytic); Life Sciences; Liver; Liver - metabolism; Lymphocytes; Lymphocytes T; Lymphocytic Choriomeningitis - pathology; Lymphocytic Choriomeningitis - prevention & control; Lymphocytic Choriomeningitis - virology; Lymphocytic choriomeningitis virus; Lymphocytic choriomeningitis virus - drug effects; Lymphocytic choriomeningitis virus - physiology; Macrophages; Medical research; Mice; Mice, Inbred C57BL; Mice, Knockout; NAD(P)H oxidase; NADPH; NADPH Oxidases - deficiency; NADPH Oxidases - genetics; NADPH Oxidases - metabolism; Neutrophils; Original Paper; Protons; Reactive oxygen species; Reactive Oxygen Species - metabolism; Regulatory subunits; Rheumatoid arthritis; Ribonucleic acid; RNA; Spleen; Spleen - metabolism; Stem Cells; Tumor necrosis factor-TNF; Viral infections; Canada; Germany; hepatitis; virus; liver cell damage; ROS

Cluster of differentiation (CD)8 + T cells are like a double edged sword during chronic viral infections because they not only promote virus elimination but also induce virus-mediated immunopathology. Elevated levels of reactive oxygen species (ROS) have been reported during virus infections. Howeve...