In vitro myotoxicity of selected cationic macromolecules used in non-viral gene delivery

• Published in: Pharmaceutical research Vol. 15; no. 5; pp. 680 - 684
• Main Authors: BRAZEAU, G. A, ATTIA, S, POXON, S, HUGHES, J. A
• Format: Journal Article
• Language: English
• Published: New York, NY Springer 01.05.1998; Springer Nature B.V
• Subjects: Animals; Biological and medical sciences; Cations; Drug toxicity and drugs side effects treatment; Gene Transfer Techniques; General pharmacology; Liposomes - toxicity; Male; Medical sciences; Muscles - drug effects; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Plasmids - genetics; Plasmids - toxicity; Polylysine - adverse effects; Rats; Rats, Sprague-Dawley; Toxicity: nervous system and muscle; Encapsulation; Pharmaceutical technology; Rat; Toxicity; Rodentia; Liposome; Drug carrier; Lysine polymer; In vitro; Vertebrata; Mammalia; Gene; Animal; DNA; Dosage form; Active ingredient; Muscle; Release

Cationic lipid/DNA complexes have been proposed as a method of in vivo gene delivery via intravenous or intramuscular injection. A concern with using these polycationic molecules is whether they are associated with tissue toxicity at the injection site. Therefore, the objective of these studies was...