Design and comprehensive characterization of dry powder inhalation aerosols of simvastatin DPPC/DPPG lung surfactant-mimic nanoparticles/microparticles for pulmonary nanomedicine

• Published in: RSC advances Vol. 14; no. 40; pp. 29413 - 29427
• Main Authors: Encinas-Basurto, David, Acosta, Maria F, Eedara, Basanth Babu, Fineman, Jeffrey R, Black, Stephen M, Mansour, Heidi M
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 12.09.2024; The Royal Society of Chemistry
• Subjects: Biocompatibility; Chemistry; Design engineering; Hypertension; Kinases; Lungs; Microparticles; Nanoparticles; Phospholipids; Respiration; Shear stress; Surfactants

The Rho Kinase (ROCK) pathway is recognized to be involved in changes that lead to remodeling in pulmonary hypertension (PH), particularly cellular processes including signaling, contraction, migration, proliferation, differentiation, and apoptosis. Simvastatin (Sim) has a potent anti-proliferative...