Novel α-N-heterocyclic thiosemicarbazone complexes: synthesis, characterization, and antimicrobial of properties investigation

In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized organic elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectra, thermogravimetric analysis, ultraviolet-visible spectrosco...

Full description

Saved in:
Bibliographic Details
Published inRSC advances Vol. 14; no. 40; pp. 29308 - 29318
Main Authors Nartop, Dilek, Hasanoğlu Özkan, Elvan, Öğütcü, Hatice, Kurnaz Yetim, Nurdan, Özdemir, İnci
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 12.09.2024
The Royal Society of Chemistry
Subjects
Bacteria
Chemistry
Fungicides
Infrared analysis
Infrared spectra
Infrared spectroscopy
Klebsiella
Magnetic permeability
Magnetic properties
NMR spectroscopy
Spectroscopic analysis
Thermogravimetric analysis
Ultraviolet spectra
Online AccessGet full text

Cover

Abstract In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized organic elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectra, thermogravimetric analysis, ultraviolet-visible spectroscopy, molar conductance and magnetic susceptibility measurements. The antimicrobial activity of these complexes was examined against ten disease-causing pathogens: Gram-positive bacteria ( ATCC9341, ATCC12228, RSKK863) and Gram-negative bacteria ( ATCC27853, ATCC27853, ATCC51342, H NCTC9018394, NCTC2966, RSKK96026) and yeast ( Y-1200-NIH). The results revealed that the α-N-heterocyclic thiosemicarbazone compounds showed potent activity. It was observed that all thiosemicarbazone complexes were more susceptible to Gram-negative strains based on the presence of an electron-withdrawing substituent (-Br/-Cl/-F). It was determined that thiosemicarbazone Cu complexes showed stronger antifungal effects.
AbstractList In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via organic elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectra, thermogravimetric analysis, ultraviolet-visible spectroscopy, molar conductance and magnetic susceptibility measurements. The in vitro antimicrobial activity of these complexes was examined against ten disease-causing pathogens: Gram-positive bacteria (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863) and Gram-negative bacteria (Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026) and yeast (Candida albicans Y-1200-NIH). The results revealed that the α-N-heterocyclic thiosemicarbazone compounds showed potent activity. It was observed that all thiosemicarbazone complexes were more susceptible to Gram-negative strains based on the presence of an electron-withdrawing substituent (–Br/–Cl/–F). It was determined that thiosemicarbazone Cu2+complexes showed stronger antifungal effects.
In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized organic elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectra, thermogravimetric analysis, ultraviolet-visible spectroscopy, molar conductance and magnetic susceptibility measurements. The antimicrobial activity of these complexes was examined against ten disease-causing pathogens: Gram-positive bacteria ( ATCC9341, ATCC12228, RSKK863) and Gram-negative bacteria ( ATCC27853, ATCC27853, ATCC51342, H NCTC9018394, NCTC2966, RSKK96026) and yeast ( Y-1200-NIH). The results revealed that the α-N-heterocyclic thiosemicarbazone compounds showed potent activity. It was observed that all thiosemicarbazone complexes were more susceptible to Gram-negative strains based on the presence of an electron-withdrawing substituent (-Br/-Cl/-F). It was determined that thiosemicarbazone Cu complexes showed stronger antifungal effects.
In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via organic elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectra, thermogravimetric analysis, ultraviolet-visible spectroscopy, molar conductance and magnetic susceptibility measurements. The in vitro antimicrobial activity of these complexes was examined against ten disease-causing pathogens: Gram-positive bacteria (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863) and Gram-negative bacteria (Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026) and yeast (Candida albicans Y-1200-NIH). The results revealed that the α-N-heterocyclic thiosemicarbazone compounds showed potent activity. It was observed that all thiosemicarbazone complexes were more susceptible to Gram-negative strains based on the presence of an electron-withdrawing substituent (-Br/-Cl/-F). It was determined that thiosemicarbazone Cu2+complexes showed stronger antifungal effects.In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via organic elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectra, thermogravimetric analysis, ultraviolet-visible spectroscopy, molar conductance and magnetic susceptibility measurements. The in vitro antimicrobial activity of these complexes was examined against ten disease-causing pathogens: Gram-positive bacteria (Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863) and Gram-negative bacteria (Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026) and yeast (Candida albicans Y-1200-NIH). The results revealed that the α-N-heterocyclic thiosemicarbazone compounds showed potent activity. It was observed that all thiosemicarbazone complexes were more susceptible to Gram-negative strains based on the presence of an electron-withdrawing substituent (-Br/-Cl/-F). It was determined that thiosemicarbazone Cu2+complexes showed stronger antifungal effects.
In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via organic elemental analysis, nuclear magnetic resonance spectroscopy, infrared spectra, thermogravimetric analysis, ultraviolet-visible spectroscopy, molar conductance and magnetic susceptibility measurements. The in vitro antimicrobial activity of these complexes was examined against ten disease-causing pathogens: Gram-positive bacteria ( Micrococcus luteus ATCC9341, Staphylococcus epidermidis ATCC12228, Bacillus cereus RSKK863) and Gram-negative bacteria ( Pseudomonas aeroginosa ATCC27853, Klebsiella pneumonia ATCC27853, Enterobacter aerogenes ATCC51342, Salmonella typhi H NCTC9018394, Shigella dysenteria NCTC2966, Proteus vulgaris RSKK96026) and yeast ( Candida albicans Y-1200-NIH). The results revealed that the α-N-heterocyclic thiosemicarbazone compounds showed potent activity. It was observed that all thiosemicarbazone complexes were more susceptible to Gram-negative strains based on the presence of an electron-withdrawing substituent (–Br/–Cl/–F). It was determined that thiosemicarbazone Cu 2+ complexes showed stronger antifungal effects. In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via 1 H-NMR, IR, TGA, UV-Vis, molar conductance and magnetic susceptibility measurements.
Author Hasanoğlu Özkan, Elvan
Kurnaz Yetim, Nurdan
Özdemir, İnci
Nartop, Dilek
Öğütcü, Hatice
Author_xml – sequence: 1
  givenname: Dilek
  surname: Nartop
  fullname: Nartop, Dilek
  organization: Department of Chemistry, Faculty of Arts and Sciences, Düzce University Düzce Turkiye
– sequence: 2
  givenname: Elvan
  orcidid: 0000-0001-7338-4015
  surname: Hasanoğlu Özkan
  fullname: Hasanoğlu Özkan, Elvan
  email: ehasanoglu@gazi.edu.tr
  organization: Department of Chemistry, Faculty of Sciences, Gazi University Ankara Turkiye ehasanoglu@gazi.edu.tr
– sequence: 3
  givenname: Hatice
  surname: Öğütcü
  fullname: Öğütcü, Hatice
  organization: Department of Field Crops, Faculty of Agriculture, Kırşehir Ahi Evran University Kırşehir Turkiye
– sequence: 4
  givenname: Nurdan
  surname: Kurnaz Yetim
  fullname: Kurnaz Yetim, Nurdan
  organization: Department of Chemistry, Faculty of Arts and Sciences, Kırklareli University Kırklareli Turkiye
– sequence: 5
  givenname: İnci
  surname: Özdemir
  fullname: Özdemir, İnci
  organization: Kocaeli University, Izmit Vocational School, Property Protection and Security Department 41285 Kocaeli Turkiye
BackLink https://www.ncbi.nlm.nih.gov/pubmed/39285885$$D View this record in MEDLINE/PubMed
BookMark eNpdkc9OFTEUhxuCAQQ2PoBp4sYFg-30z8y4IYQokBDcyHpypnOGKZlpx7b3hsvGZ_JFfCaLgkGbNG3S73z9nfY12XbeISFvODvmTDQfehmAScZKs0X2SiZ1UTLdbL_Y75LDGO9YHlrxUvMdsiuaslZ1rfbI92u_xon-_FFcFyMmDN5szGQNTaP1EWdrIHTwkO-kxs_LhPcYP9K4cWnEaOMRNSMEMLnQPkCy3h1RcH2eyeba4DsLE_UDXYJfMCSLkVq3xpjs7W_8gLwaYIp4-LTuk5vPn76eXRRXX84vz06viiUnToXSppSiYvVQqb7jXFe8AyU5ql5AA0zz_Bii7_QgoO-VMVLVUDdDPUBXNYqLfXLyx7usuhl7gy4FmNol2BnCpvVg239PnB3bW79uOZfZ3MhseP9kCP7bKnfQzjYanCZw6FexFTynaHRZ1Rl99x9651fB5f4y9SiUqhSZevsy0t8sz58jfgFQGZdX
ContentType Journal Article
Copyright This journal is © The Royal Society of Chemistry.
Copyright Royal Society of Chemistry 2024
This journal is © The Royal Society of Chemistry 2024 The Royal Society of Chemistry
Copyright_xml – notice: This journal is © The Royal Society of Chemistry.
– notice: Copyright Royal Society of Chemistry 2024
– notice: This journal is © The Royal Society of Chemistry 2024 The Royal Society of Chemistry
DBID NPM
7SR
8BQ
8FD
JG9
7X8
5PM
DOI 10.1039/d4ra04002c
DatabaseName PubMed
Engineered Materials Abstracts
METADEX
Technology Research Database
Materials Research Database
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle PubMed
Materials Research Database
Engineered Materials Abstracts
Technology Research Database
METADEX
MEDLINE - Academic
DatabaseTitleList Materials Research Database
PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Chemistry
EISSN 2046-2069
EndPage 29318
ExternalDocumentID 39285885
Genre Journal Article
GrantInformation_xml – fundername: ;
  grantid: 2021.05.03.1215
GroupedDBID -JG
0-7
0R~
53G
AAFWJ
AAHBH
AAIWI
AAJAE
AARTK
AAWGC
AAXHV
ABEMK
ABGFH
ABPDG
ABXOH
ACGFS
ADBBV
ADMRA
AEFDR
AENEX
AESAV
AFLYV
AFVBQ
AGEGJ
AGRSR
AGSTE
AHGCF
AKBGW
ALMA_UNASSIGNED_HOLDINGS
ANUXI
APEMP
ASKNT
AUDPV
BCNDV
BLAPV
BSQNT
C6K
EBS
EE0
EF-
GROUPED_DOAJ
H13
HZ~
H~N
J3I
M~E
NPM
O9-
OK1
PGMZT
R7C
R7G
RCNCU
RPM
RPMJG
RRC
RSCEA
RVUXY
SLH
SMJ
ZCN
7SR
8BQ
8FD
JG9
7X8
5PM
AFPKN
ID FETCH-LOGICAL-p261t-56c243708f75db11671ba541e5d3a9a0611033db6f3add5cc458a89f8fab79513
IEDL.DBID RPM
ISSN 2046-2069
IngestDate Tue Sep 17 05:23:31 EDT 2024
Sat Oct 26 04:05:43 EDT 2024
Thu Oct 10 21:21:00 EDT 2024
Tue Oct 29 09:11:08 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 40
Language English
License This journal is © The Royal Society of Chemistry.
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-p261t-56c243708f75db11671ba541e5d3a9a0611033db6f3add5cc458a89f8fab79513
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ORCID 0000-0001-7338-4015
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11403394/
PMID 39285885
PQID 3111404523
PQPubID 2047525
PageCount 11
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_11403394
proquest_miscellaneous_3106196278
proquest_journals_3111404523
pubmed_primary_39285885
PublicationCentury 2000
PublicationDate 2024-09-12
PublicationDateYYYYMMDD 2024-09-12
PublicationDate_xml – month: 09
  year: 2024
  text: 2024-09-12
  day: 12
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: Cambridge
PublicationTitle RSC advances
PublicationTitleAlternate RSC Adv
PublicationYear 2024
Publisher Royal Society of Chemistry
The Royal Society of Chemistry
Publisher_xml – name: Royal Society of Chemistry
– name: The Royal Society of Chemistry
SSID ssj0000651261
Score 2.4622152
Snippet In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized...
In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via...
In this paper, eight novel α-N-heterocyclic thiosemicarbazone complexes were synthesized in search of new biologically active compounds, and characterized via...
SourceID pubmedcentral
proquest
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 29308
SubjectTerms Bacteria
Chemistry
Fungicides
Infrared analysis
Infrared spectra
Infrared spectroscopy
Klebsiella
Magnetic permeability
Magnetic properties
NMR spectroscopy
Spectroscopic analysis
Thermogravimetric analysis
Ultraviolet spectra
Title Novel α-N-heterocyclic thiosemicarbazone complexes: synthesis, characterization, and antimicrobial of properties investigation
URI https://www.ncbi.nlm.nih.gov/pubmed/39285885
https://www.proquest.com/docview/3111404523
https://www.proquest.com/docview/3106196278
https://pubmed.ncbi.nlm.nih.gov/PMC11403394
Volume 14
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV09b9swED3E6dAuRdNPp4nBAh1N2zJJi-pWGAmCAjWKoi7cySApChZgU4alBEmW_qb-kfymHCnLcYpOHTSRkvhx4j2K794BfBxohk5YS2p9DBrPmKCaCU4RixgVR4YPTGBbTEYXU_5lJmYHMGpiYQJp3-i855arnssXgVu5Xpl-wxPrf_s6jrzIHEt4vwUttNC9PXq9_qITG0WNFilL-infKG-sQ_MvHPk3HXLPv5y_gOdbYEg-1w04ggPrXsLTcZOP7RX8nhRXdknu_tAJXXgSS2FuzDI3pFrkRRnC_jda3RbOksATt9e2_ETKG4cQr8zLLjE7beY69LJLlEvxqvJVHuSY8PVFRtb-9_zG66yS_EGEo3CvYXp-9mN8QbfpE-gau19RMTJebXAgs1ik2p-3RFoJHlmRMpUodOQ4OMyH4TFc5IQxXEglk0xmSscIvNgbOHTY6HdAeCriJDYiHg6Nf6RKEcd5sUEt1ECmaRtOmmGdb7-Bcs4iP08cd7pt-LArxkHzRxLK2eLS18Fm-Pw_sg1v61mYr2uZjTkiNymkFG2Qj-ZnV8ErYz8uQYMJCtmNgRz__63v4dkQe0hDtogTOKw2l_YU8UelO2Hf3glG14En339OZ7_uATAx5P8
link.rule.ids 230,315,730,783,787,867,888,27938,27939,53806,53808
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LctMwFL1TyqJseFMCLYgZlnViR5Itd9fJ0AnQZli0Q3ceSZYnHhI5EzsM7YZv4kf4Jq7kOH0MG1h4JdmW79XjyDr3XID3oaK4CCsRGBeDxgrKA0U5CxCLaJlEmoXasy0m8ficfbrgF1sQd7EwnrSvVdm3s3nfllPPrVzM9aDjiQ2-nI4iJzJHUza4B_dxwIbxjV16OwPjMhZHnRopTQc5W0rXXYf6b0jyLiHyxgpz_Ai-dm1riSXf-qtG9fXVHdnGf2_8Y3i4Bp3kqC1_AlvGPoWdUZfr7Rn8nFTfzYz8_hVMgqkjyFT6Us9KTZppWdVeUmCp5FVlDfEcdPPD1IekvrQIH-uyPiB6o_vchnUeEGlzvJpyXnqpJ3x9VZCF-_W_dBqupLwW-Kjsczg__nA2Ggfr1AzBAg3bBDzWTskwFEXCc-XOciIlOYsMz6lMJYIENDt1IX4UJ1CuNeNCirQQhVQJgjr6ArYtNvolEJbzJE00T4ZD7R4pc8SITshQcRmKPO_BXuewbD2-6oxGzowMd9E9eLcpRqO54w5pTbVydbAZLreQ6MFu699s0Up4ZIgKBReC90Dc8vymglPdvl2C_vTq253_Xv3_rW9hZ3x2epKdfJx8fg0Phvi1gc9KsQfbzXJl9hHnNOqN79R_AA0EBGo
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3LbtQwFLWgSMCmPAsDBYzEsp4kY3visEMDo_IadUGlSiwiv6KJmHGiSaai3fSb-iP9pl7nMbQVqy6yspPY9_pxrHt8LkIfQkVhE1aCWH8HjWWUE0U5I4BFtIwjzULdsC1m4_1D9u2IH3WsyqqjVTqt8qFbLIcunzfcynKpg54nFhz8nEReZI4mLChNFtxF92DShuLKSb1dhWErG0e9IilNAsNW0g_Zkf4fmrxJiryyy0wfod99-1pyyZ_hulZDfXpDuvF2HXiMtjvwiT-1dZ6gO9Y9RQ8mfc63Z-hsVhzbBb44JzMy90SZQp_oRa5xPc-LqpEWWCl5WjiLGy66_Wurj7g6cQAjq7zaw3qj_9xe79zD0hl46nyZN5JP8Psiw6UPAay8livO_wl9FO45Opx--TXZJ12KBlKCcWvCx9orGoYii7lRPqYTKclZZLmhMpEAFsD01F_1o7CQcq0ZF1IkmcikigHc0R205aDRLxFmhsdJrHk8Gmn_SWkAK3pBQ8VlKIwZoN3eaWk3z6qURt6UDE7TA_R-UwxG82EP6Wyx9nWgGT7HkBigF62P07KV8kgBHQouBB8gcc37mwpefft6Cfi0UeHuffjq9q--Q_cPPk_TH19n31-jhyPoLGmSU-yirXq1tm8A7tTqbTOuLwEKMAbq
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Novel+%CE%B1-N-heterocyclic+thiosemicarbazone+complexes%3A+synthesis%2C+characterization%2C+and+antimicrobial+of+properties+investigation&rft.jtitle=RSC+advances&rft.au=Nartop%2C+Dilek&rft.au=Elvan+Hasano%C4%9Flu+%C3%96zkan&rft.au=%C3%96%C4%9F%C3%BCtc%C3%BC%2C+Hatice&rft.au=Nurdan+Kurnaz+Yetim&rft.date=2024-09-12&rft.pub=Royal+Society+of+Chemistry&rft.eissn=2046-2069&rft.volume=14&rft.issue=40&rft.spage=29308&rft.epage=29318&rft_id=info:doi/10.1039%2Fd4ra04002c&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2046-2069&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2046-2069&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2046-2069&client=summon