Reelin signaling modulates GABAB receptor function in the neocortex

• Published in: Journal of neurochemistry Vol. 156; no. 5; pp. 589 - 603
• Main Authors: Hamad, Mohammad I. K., Jbara, Abdalrahim, Rabaya, Obada, Petrova, Petya, Daoud, Solieman, Melliti, Nesrine, Meseke, Maurice, Lutz, David, Petrasch‐Parwez, Elisabeth, Schwitalla, Jan Claudius, Mark, Melanie D., Herlitze, Stefan, Reiss, Gebhard, Herz, Joachim, Förster, Eckart
• Format: Journal Article
• Language: English
• Published: New York Blackwell Publishing Ltd 01.03.2021
• Subjects: ApoER2 and VLDLR; Apolipoprotein E; Baclofen; Blocking; calcium imaging; Cerebral cortex; Deactivation; GABAB receptors; Neocortex; network activity; Phosphorylation; Proteolysis; Receptors; Reelin; Reelin protein; Serine; γ-Aminobutyric acid B receptors

Reelin is a protein that is best known for its role in controlling neuronal layer formation in the developing cortex. Here, we studied its role for post‐natal cortical network function, which is poorly explored. To preclude early cortical migration defects caused by Reelin deficiency, we used a cond...