Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study

• Published in: Neurology Vol. 81; no. 17; p. 1531
• Main Authors: Ding, Hongliu, Dhima, Kaltra, Lockhart, Kaitlin C, Locascio, Joseph J, Hoesing, Ashley N, Duong, Karen, Trisini-Lipsanopoulos, Ana, Hayes, Michael T, Sohur, U Shivraj, Wills, Anne-Marie, Mollenhauer, Brit, Flaherty, Alice W, Hung, Albert Y, Mejia, Nicte, Khurana, Vikram, Gomperts, Stephen N, Selkoe, Dennis J, Schwarzschild, Michael A, Schlossmacher, Michael G, Hyman, Bradley T, Sudarsky, Lewis R, Growdon, John H, Scherzer, Clemens R
• Format: Journal Article
• Language: English
• Published: United States 22.10.2013
• Subjects: Aged; Biomarkers - metabolism; Case-Control Studies; Cholecalciferol - deficiency; Cross-Sectional Studies; Female; Humans; Longitudinal Studies; Male; Middle Aged; Parkinson Disease - etiology; Parkinson Disease - metabolism; Prevalence; Severity of Illness Index; Vitamin D Deficiency - complications; Vitamin D Deficiency - diagnosis

To conclusively test for a specific association between the biological marker 25-hydroxy-vitamin D3, a transcriptionally active hormone produced in human skin and liver, and the prevalence and severity of Parkinson disease (PD). We used liquid chromatography/tandem mass spectrometry to establish an...