Age-dependent alterations of decorin glycosaminoglycans in human skin

• Published in: Scientific reports Vol. 3; no. 1; p. 2422
• Main Authors: Li, Yong, Liu, Ying, Xia, Wei, Lei, Dan, Voorhees, John J., Fisher, Gary J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.08.2013; Nature Publishing Group
• Subjects: 631/337/458/1524; 631/443/7; 631/45/612/1231; 631/80/509; Adult; Age; Aged; Aged, 80 and over; Aging - metabolism; Collagen; Collagen (type I); Decorin; Decorin - metabolism; Dermis; Extracellular matrix; Extracellular Matrix Proteins - metabolism; Fibrils; Fibroblasts; Gene expression; Geriatrics; Glycosaminoglycans; Glycosaminoglycans - metabolism; Human subjects; Humanities and Social Sciences; Humans; Mechanical properties; Middle Aged; multidisciplinary; Older people; Proteins; Proteoglycans; Science; Skin; Skin - metabolism; Skin Aging - physiology; Tissue Distribution; Young Adult

Proteoglycans, a family of glycosaminoglycan (GAG) conjugated proteins, are important constituents of human skin connective tissue (dermis) and are essential for maintaining mechanical strength of the skin. Age-related alterations of dermal proteoglycans have not been fully elucidated. We quantified...