Response to suxamethonium during propofol-fentanyl-N2O/O2 anaesthesia in a patient with active myasthenia gravis receiving long-term anticholinesterase therapy

• Published in: Anaesthesia Vol. 49; no. 6; p. 509
• Main Authors: Vanlinthout, L E, Robertson, E N, Booij, L H
• Format: Journal Article
• Language: English
• Published: England 01.06.1994
• Subjects: Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Dose-Response Relationship, Drug; Drug Resistance; Female; Humans; Muscle Contraction - drug effects; Myasthenia Gravis - drug therapy; Myasthenia Gravis - enzymology; Myasthenia Gravis - physiopathology; Myasthenia Gravis - surgery; Nitrous Oxide; Oxygen; Propofol; Pyridostigmine Bromide - therapeutic use; Succinylcholine - pharmacology

We describe the effect of repeated suxamethonium doses during propofol-fentanyl-N2O/O2 anaesthesia in a 29-year-old woman with active myasthenia gravis receiving chronic pyridostigmine therapy. Despite adequate pre-operative pseudocholinesterase activity, suxamethonium resistance occurred. Neither b...