Association of the 5‐HT2A receptor gene promoter polymorphism‐1438G/A with anorexia nervosa and psychopathological traits in the Chinese Han population: A preliminary study

• Published in: Asia-Pacific psychiatry Vol. 9; no. 3
• Main Authors: Kang, Qing, Chen, Jue, Yu, Shunying, Yuan, Aihua, Zhang, Yanxia, Zhang, Ran, Jiang, Wenhui, Zhang, Chen, Zhang, Haiyin, Zhang, Mingdao, Xiao, Zeping
• Format: Journal Article
• Language: English
• Published: Richmond Wiley Subscription Services, Inc 01.09.2017
• Subjects: 1438G/A; 5‐HT2A receptor gene promoter polymorphism; Anorexia; anorexia nervosa; Bulimia; Chinese Han; psychopathological traits of eating‐disordered behavior
• ISSN: 1758-5864; 1758-5872; 1758-5872
• DOI: 10.1111/appy.12284

Objective The aim of the study was to explore the possible role of the 5‐HT2A‐1438G/A polymorphism in the susceptibility to anorexia nervosa (AN) in the Chinese Han population. Methods The ‐1438G/A polymorphism of 249 female AN patients, 228 matched healthy controls, and 198 trios was genotyped using SNaP shot assay. Psychopathological traits of eating‐disordered behaviors in AN subjects were examined using the Chinese version of the Eating Disorder Examination Questionnaire. Results Neither the case‐control analysis nor the transmission disequilibrium test revealed significant associations between the ‐1438G/A polymorphism and AN (P > .05). However, AA homozygote patients with AN had lower weight and shape concern scores of the EDE‐Q6.0 than those of GA heterozygotes (P < .05). Discussion Our findings suggested that female AN patients with 5‐HT2A −1438AA genotype may be characterized by less severe eating‐disordered psychopathological traits in the Chinese Han population.