Immunogenicity of Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV; Sinopharm) and Short-Term Clinical Outcomes in Vaccinated Solid Organ Transplant Recipients: A Prospective Cohort Study
BackgroundImmunocompromised patients have lower seroconversion rate in response to COVID-19 vaccination. The aim of this study is to evaluate the humoral immune response with short-term clinical outcomes in solid organ transplant recipients vaccinated with SARS-CoV-2 vaccine (BBIBP-CorV; Sinopharm)....
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Published in | Advances in experimental medicine and biology Vol. 1412; p. 357 |
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United States
2023
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Abstract | BackgroundImmunocompromised patients have lower seroconversion rate in response to COVID-19 vaccination. The aim of this study is to evaluate the humoral immune response with short-term clinical outcomes in solid organ transplant recipients vaccinated with SARS-CoV-2 vaccine (BBIBP-CorV; Sinopharm).MethodsThis prospective cohort was conducted from March to December 2021 in Abu Ali Sina hospital, Iran. All transplant recipients, older than 18 years were recruited. The patients received two doses of Sinopharm vaccine 4 weeks apart. Immunogenicity was evaluated through assessment of antibodies against the receptor-binding domain (RBD) of SARS-CoV-2 after the first and second dose of vaccine. The patients were followed up for 6 months after vaccination.ResultsOut of 921 transplant patients, 115 (12.5%) and 239 (26%) had acceptable anti S-RBD immunoglobulin G (IgG) levels after the first and second dose, respectively. Eighty patients (8.68%) got infected with COVID-19 which led to 45 (4.9%) of patients being hospitalized. None of the patients died during follow-up period. Twenty-four (10.9%) liver transplant recipients developed liver enzyme elevation, and increased serum creatinine was observed in 86 (13.5%) kidney transplant patients. Two patients experienced biopsy-proven rejection without any graft loss.ConclusionOur study revealed that humoral response rate of solid organ transplant recipients to Sinopharm vaccine was low. |
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AbstractList | BackgroundImmunocompromised patients have lower seroconversion rate in response to COVID-19 vaccination. The aim of this study is to evaluate the humoral immune response with short-term clinical outcomes in solid organ transplant recipients vaccinated with SARS-CoV-2 vaccine (BBIBP-CorV; Sinopharm).MethodsThis prospective cohort was conducted from March to December 2021 in Abu Ali Sina hospital, Iran. All transplant recipients, older than 18 years were recruited. The patients received two doses of Sinopharm vaccine 4 weeks apart. Immunogenicity was evaluated through assessment of antibodies against the receptor-binding domain (RBD) of SARS-CoV-2 after the first and second dose of vaccine. The patients were followed up for 6 months after vaccination.ResultsOut of 921 transplant patients, 115 (12.5%) and 239 (26%) had acceptable anti S-RBD immunoglobulin G (IgG) levels after the first and second dose, respectively. Eighty patients (8.68%) got infected with COVID-19 which led to 45 (4.9%) of patients being hospitalized. None of the patients died during follow-up period. Twenty-four (10.9%) liver transplant recipients developed liver enzyme elevation, and increased serum creatinine was observed in 86 (13.5%) kidney transplant patients. Two patients experienced biopsy-proven rejection without any graft loss.ConclusionOur study revealed that humoral response rate of solid organ transplant recipients to Sinopharm vaccine was low. |
Author | Sohrevardi, Seyed Mojtaba Golshan, Mehdi Nikeghbalian, Saman Nikoupour, Hamed Malekhosseini, Seyed Ali Haem, Elham Mehrdad, Goli Shamsaeefar, Alireza Sahebkar, Amirhossein Chamanpara, Parisa Roozbeh, Jamshid Geramizadeh, Bita Moghadami, Mohsen Vatankhah, Pooya Jalali, Seyed Soroush Gholami, Siavash Zare, Zahra Jamialahmadi, Tannaz Shafiekhani, Mojtaba Mirjalili, Mahtabalsadat |
Author_xml | – sequence: 1 givenname: Mojtaba surname: Shafiekhani fullname: Shafiekhani, Mojtaba organization: Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 2 givenname: Mahtabalsadat surname: Mirjalili fullname: Mirjalili, Mahtabalsadat organization: Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 3 givenname: Siavash surname: Gholami fullname: Gholami, Siavash organization: Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 4 givenname: Pooya surname: Vatankhah fullname: Vatankhah, Pooya organization: Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 5 givenname: Jamshid surname: Roozbeh fullname: Roozbeh, Jamshid organization: Shiraz Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 6 givenname: Goli surname: Mehrdad fullname: Mehrdad, Goli organization: Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 7 givenname: Elham surname: Haem fullname: Haem, Elham organization: Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 8 givenname: Zahra surname: Zare fullname: Zare, Zahra organization: Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 9 givenname: Seyed Soroush surname: Jalali fullname: Jalali, Seyed Soroush organization: Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 10 givenname: Mehdi surname: Golshan fullname: Golshan, Mehdi organization: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 11 givenname: Saman surname: Nikeghbalian fullname: Nikeghbalian, Saman organization: Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 12 givenname: Parisa surname: Chamanpara fullname: Chamanpara, Parisa organization: Department of Biostatistics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 13 givenname: Alireza surname: Shamsaeefar fullname: Shamsaeefar, Alireza organization: Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 14 givenname: Mohsen surname: Moghadami fullname: Moghadami, Mohsen organization: Department of Internal Medicine, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 15 givenname: Hamed surname: Nikoupour fullname: Nikoupour, Hamed organization: Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 16 givenname: Seyed Ali surname: Malekhosseini fullname: Malekhosseini, Seyed Ali organization: Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical Sciences, Shiraz, Iran – sequence: 17 givenname: Seyed Mojtaba surname: Sohrevardi fullname: Sohrevardi, Seyed Mojtaba organization: Department of Clinical Pharmacy, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran – sequence: 18 givenname: Tannaz surname: Jamialahmadi fullname: Jamialahmadi, Tannaz organization: Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran – sequence: 19 givenname: Amirhossein surname: Sahebkar fullname: Sahebkar, Amirhossein organization: Department of Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran – sequence: 20 givenname: Bita surname: Geramizadeh fullname: Geramizadeh, Bita organization: Shiraz Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran |
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Keywords | COVID-19 Sinopharm Liver transplant Humoral response Kidney transplant Vaccination |
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Snippet | BackgroundImmunocompromised patients have lower seroconversion rate in response to COVID-19 vaccination. The aim of this study is to evaluate the humoral... |
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SubjectTerms | Antibodies, Viral COVID-19 - prevention & control COVID-19 Vaccines Humans Kidney Transplantation Prospective Studies SARS-CoV-2 Transplant Recipients |
Title | Immunogenicity of Inactivated SARS-CoV-2 Vaccine (BBIBP-CorV; Sinopharm) and Short-Term Clinical Outcomes in Vaccinated Solid Organ Transplant Recipients: A Prospective Cohort Study |
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