Human experimental pain models 2: the cold pressor model

The cold pressor test is a reliable pain model in which subjects submerge their hands and forearms into ice water while onset to pain, pain intensity, and tolerance are assessed. Although originally developed as a model for hypertension, the paradigm leads to development of reproducible pain respons...

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Published inMethods in molecular biology (Clifton, N.J.) Vol. 617; p. 165
Main Authors Modir, James G, Wallace, Mark S
Format Journal Article
LanguageEnglish
Published United States 01.01.2010
Subjects
Cold Temperature
Humans
Models, Biological
Pain - physiopathology
Pain Measurement - instrumentation
Pain Measurement - methods
Pain Threshold
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Abstract The cold pressor test is a reliable pain model in which subjects submerge their hands and forearms into ice water while onset to pain, pain intensity, and tolerance are assessed. Although originally developed as a model for hypertension, the paradigm leads to development of reproducible pain responses allowing assessment to analgesic medications. However, analgesic variability to various medications has been observed. A recent study suggests that methodological discrepancies may contribute to such inconsistencies. The model may be more reproducible by utilizing consistent protocols.
AbstractList The cold pressor test is a reliable pain model in which subjects submerge their hands and forearms into ice water while onset to pain, pain intensity, and tolerance are assessed. Although originally developed as a model for hypertension, the paradigm leads to development of reproducible pain responses allowing assessment to analgesic medications. However, analgesic variability to various medications has been observed. A recent study suggests that methodological discrepancies may contribute to such inconsistencies. The model may be more reproducible by utilizing consistent protocols.
Author Wallace, Mark S
Modir, James G
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SubjectTerms Cold Temperature
Humans
Models, Biological
Pain - physiopathology
Pain Measurement - instrumentation
Pain Measurement - methods
Pain Threshold
Title Human experimental pain models 2: the cold pressor model
URI https://www.ncbi.nlm.nih.gov/pubmed/20336421
Volume 617
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