Predicting Tau accumulation in cerebral cortex with multivariate MRI morphometry measurements, sparse coding, and correntropy

• Published in: Proceedings of SPIE, the international society for optical engineering Vol. 12088; pp. 120880O - 120880O-10
• Main Authors: Wu, Jianfeng, Zhu, Wenhui, Su, Yi, Gui, Jie, Lepore, Natasha, Reiman, Eric M, Caselli, Richard J, Thompson, Paul M, Chen, Kewei, Wang, Yalin
• Format: Conference Proceeding Journal Article
• Language: English
• Published: United States SPIE 01.11.2021
• Subjects: Dictionary and Correntropy-induced Sparse Coding; Hippocampal Multivariate Morphometry Statistics (MMS); Alzheimer’s disease; Braak12; Braak34; Tau deposition

Biomarker-assisted diagnosis and intervention in Alzheimer’s disease (AD) may be the key to prevention breakthroughs. One of the hallmarks of AD is the accumulation of tau plaques in the human brain. However, current methods to detect tau pathology are either invasive (lumbar puncture) or quite cost...