Internalization of Clostridium perfringens α‐toxin leads to ERK activation and is involved on its cytotoxic effect

• Published in: Cellular microbiology Vol. 16; no. 4; pp. 535 - 547
• Main Authors: Monturiol‐Gross, Laura, Flores‐Díaz, Marietta, Campos‐Rodríguez, Diana, Mora, Rodrigo, Rodríguez‐Vega, Mariela, Marks, David L., Alape‐Girón, Alberto
• Format: Journal Article
• Language: English
• Published: England 01.04.2014
• Subjects: Bacterial Toxins - metabolism; Bacterial Toxins - toxicity; Calcium-Binding Proteins - metabolism; Calcium-Binding Proteins - toxicity; Cell Line; Endocytosis; Extracellular Signal-Regulated MAP Kinases - metabolism; Humans; MAP Kinase Signaling System; Type C Phospholipases - metabolism; Type C Phospholipases - toxicity

Summary Clostridium perfringens phospholipase C (CpPLC), also called α‐toxin, plays a key role in the pathogenesis of gas gangrene. CpPLC may lead to cell lysis at concentrations that cause extensive degradation of plasma membrane phospholipids. However, at sublytic concentrations it induces cytotox...