Role of sodium thiosulfate therapy in the treatment of digital necrosis due to Mönckeberg sclerosis

• Published in: Hemodialysis international Vol. 18; no. 2; pp. 531 - 535
• Main Authors: Brucculeri, Michael, Rullan, Eugenia, Zanchi, Antonela, Marcotte, Anthony
• Format: Journal Article
• Language: English
• Published: Canada 01.04.2014
• Subjects: Diabetes Mellitus, Type 2 - pathology; dialysis; Digital necrosis; Fingers - blood supply; Fingers - pathology; Fingers - surgery; gangrene; Gangrene - pathology; Humans; Kidney Failure, Chronic - pathology; Kidney Failure, Chronic - therapy; Male; Middle Aged; Monckeberg Medial Calcific Sclerosis - drug therapy; Monckeberg Medial Calcific Sclerosis - pathology; Mönckeberg Sclerosis; Necrosis - drug therapy; Necrosis - etiology; Necrosis - surgery; Renal Dialysis - methods; sodium thiosulfate; Thiosulfates - administration & dosage; vascular calcification; dialysis; sodium thiosulfate; Digital necrosis; gangrene; Mönckeberg Sclerosis; vascular calcification

Accelerated vascular calcification is a well‐described complication of chronic kidney disease often affecting large and small vessels alike through a variety of mechanisms. Accordingly, dysregulation of calcium and phosphate balance, vitamin D metabolism, hyperparathyroidism, and endothelial injury...