Robust, scalable construction of an electrophilic deuterated methylthiolating reagent: facile access to SCD3-containing scaffolds

• Published in: Chemical communications (Cambridge, England) Vol. 58; no. 18; pp. 3015 - 3018
• Main Authors: Xiao, Xiao, Huang, Yin-Qiu, Tian, Hong-Yu, Bai, Jun, Cheng, Fei, Wang, Xu, Ke, Miao-Lin, Chen, Fen-Er
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 01.03.2022; Royal Society of Chemistry
• Subjects: Chemistry; Chemistry, Multidisciplinary; Deuteration; Deuterium; Lewis acids; Lewis bases; Nucleophiles; Physical Sciences; Reagents; Science & Technology; DRUG; HYDROGEN ISOTOPE; METHYLATION; PATHWAY; CHEMISTRY; DISCOVERY; DEUTERIUM

We have established a practical and concise method for the straightforward access of a universal deuterated methylthiolating reagent through a one-pot gram-scale operation under mild conditions. This odourless electrophilic SCD3 reagent was widely applied to react with numerous representative nucleo...