Short‐term in vivo modifications of platelet NADPH oxidase 2 (NOX2) and prostaglandin F2α in HIV‐1 patients on abacavir‐based therapies

• Published in: HIV medicine Vol. 17; no. 10; pp. 774 - 777
• Main Authors: Pastori, D, Esposito, A, Carnevale, R, Bartimoccia, S, Nocella, C, Fantauzzi, A, Pignatelli, P, Violi, F, Mezzaroma, I
• Format: Journal Article
• Language: English
• Published: 01.11.2016
• Subjects: abacavir; HIV‐1 infection; isoprostanes; NADPH oxidase; platelet activation

Objectives The aim of the study was to investigate the in vivo effect of abacavir (ABC) on platelet oxidative stress. Methods We performed a randomized pilot study including 39 HIV‐1‐infected patients, 17 on zidovudine/lamivudine (ZDV/3TC) and 22 on tenofovir/emtricitabine (TDF/FTC). Ten patients on...