p53 Codon 72 polymorphism in oral exfoliated cells in a Sudanese population

• Published in: In vivo (Athens) Vol. 26; no. 1; p. 59
• Main Authors: Sand, Lars, Jalouli, Miranda M, Jalouli, Jamshid, Sapkota, Dipak, Ibrahim, Salah O
• Format: Journal Article
• Language: English
• Published: Greece 01.01.2012
• Subjects: Adolescent; Adult; Aged; Carcinoma, Squamous Cell - etiology; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - pathology; Codon - genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Mouth Mucosa - cytology; Mouth Mucosa - metabolism; Mouth Mucosa - virology; Mouth Neoplasms - etiology; Mouth Neoplasms - genetics; Mouth Neoplasms - pathology; Nitrosamines - poisoning; oral squamous cell carinoma; p53 codon 72; p53 polymorphism; Papillomavirus Infections - complications; Papillomavirus Infections - virology; Polymorphism, Genetic; Risk Factors; Sudan; Tobacco, Smokeless - chemistry; Tobacco, Smokeless - poisoning; toombak; Tumor Suppressor Protein p53 - genetics; Young Adult; Sudan

Earlier studies have investigated the tumor suppressor gene p53 as a co-factor in the development of oral squamous cell carcinoma (OSCC). Our previous studies have indicated that chronic use of Sudanese snuff (toombak) and the presence of human papilloma virus (HPV) may be involved in the high preva...