TNF-alpha modulates adipose macrophage polarization to M1 phenotype in response to scorpion venom

• Published in: Inflammation research Vol. 64; no. 11; pp. 929 - 936
• Main Authors: Ait-Lounis, Aouatef, Laraba-Djebari, Fatima
• Format: Journal Article
• Language: English
• Published: Basel Springer Basel 01.11.2015; Springer Nature B.V
• Subjects: Adipose Tissue - cytology; Adipose Tissue - immunology; Allergology; Androctonus australis; Animals; Biomedical and Life Sciences; Biomedicine; Cytokines - antagonists & inhibitors; Cytokines - genetics; Cytokines - immunology; Dermatology; Etanercept - pharmacology; Gene Expression - drug effects; Immunology; Macrophages - drug effects; Macrophages - immunology; Male; Mice; Neurology; Nitric Oxide Synthase Type II - genetics; Original Research Paper; Pharmacology/Toxicology; Phenotype; Rheumatology; RNA, Messenger - metabolism; Scorpion Venoms - pharmacology; IL12p40; venom; NOSi; TNF- α antagonist; Ftox-G50 venom; IL23; Aah venom

Objective We previously reported that Androctonus australis hector (Aah ) venom and its toxic fraction affect adipose tissue metabolism. However, the contribution of immune system and the role of adipose tissue macrophages (ATMs) in the progression of inflammation induced by scorpion venom remain la...