TNF-alpha modulates adipose macrophage polarization to M1 phenotype in response to scorpion venom

Objective We previously reported that Androctonus australis hector (Aah ) venom and its toxic fraction affect adipose tissue metabolism. However, the contribution of immune system and the role of adipose tissue macrophages (ATMs) in the progression of inflammation induced by scorpion venom remain la...

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Published inInflammation research Vol. 64; no. 11; pp. 929 - 936
Main Authors Ait-Lounis, Aouatef, Laraba-Djebari, Fatima
Format Journal Article
LanguageEnglish
Published Basel Springer Basel 01.11.2015
Springer Nature B.V
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Abstract Objective We previously reported that Androctonus australis hector (Aah ) venom and its toxic fraction affect adipose tissue metabolism. However, the contribution of immune system and the role of adipose tissue macrophages (ATMs) in the progression of inflammation induced by scorpion venom remain largely unknown. Methods Here we evaluate the capacity of the toxic fraction of Aah venom (FTox-G50) to induce the expression of M1 and M2 markers genes on adipose tissue and isolated stromal vascular cells (SVC). Quantitative real-time PCR was performed on the SVC 24 h after FTox-G50 venom injection to assess the gene expressions of IL12p40, IL23, and other macrophages-associated markers. Results We found that ATM from FTox-G50-venom-injected mice markedly increased the expressions of IL-12p40 and IL-23. Furthermore, the expression of nitric oxide synthase 2 (an M1 marker) was up-regulated, but the expression of Arginase1 (an M2 marker) was not. Systemic injection of a chemical inhibitor directed against TNF-α binding reduced the expression of inflammatory M1 macrophage markers and the MAPKpk2 gene, a key mediator of inflammatory signaling. Conclusion These results indicate that TNF-α is a physiological regulator of inflammation and macrophage activation induced by scorpion venom.
AbstractList Objective We previously reported that Androctonus australis hector (Aah) venom and its toxic fraction affect adipose tissue metabolism. However, the contribution of immune system and the role of adipose tissue macrophages (ATMs) in the progression of inflammation induced by scorpion venom remain largely unknown. Methods Here we evaluate the capacity of the toxic fraction of Aah venom (FTox-G50) to induce the expression of M1 and M2 markers genes on adipose tissue and isolated stromal vascular cells (SVC). Quantitative real-time PCR was performed on the SVC 24 h after FTox-G50 venom injection to assess the gene expressions of IL12p40, IL23, and other macrophages-associated markers. Results We found that ATM from FTox-G50-venom-injected mice markedly increased the expressions of IL-12p40 and IL-23. Furthermore, the expression of nitric oxide synthase 2 (an M1 marker) was up-regulated, but the expression of Arginase1 (an M2 marker) was not. Systemic injection of a chemical inhibitor directed against TNF-[alpha] binding reduced the expression of inflammatory M1 macrophage markers and the MAPKpk2 gene, a key mediator of inflammatory signaling. Conclusion These results indicate that TNF-[alpha] is a physiological regulator of inflammation and macrophage activation induced by scorpion venom.
Objective We previously reported that Androctonus australis hector (Aah ) venom and its toxic fraction affect adipose tissue metabolism. However, the contribution of immune system and the role of adipose tissue macrophages (ATMs) in the progression of inflammation induced by scorpion venom remain largely unknown. Methods Here we evaluate the capacity of the toxic fraction of Aah venom (FTox-G50) to induce the expression of M1 and M2 markers genes on adipose tissue and isolated stromal vascular cells (SVC). Quantitative real-time PCR was performed on the SVC 24 h after FTox-G50 venom injection to assess the gene expressions of IL12p40, IL23, and other macrophages-associated markers. Results We found that ATM from FTox-G50-venom-injected mice markedly increased the expressions of IL-12p40 and IL-23. Furthermore, the expression of nitric oxide synthase 2 (an M1 marker) was up-regulated, but the expression of Arginase1 (an M2 marker) was not. Systemic injection of a chemical inhibitor directed against TNF-α binding reduced the expression of inflammatory M1 macrophage markers and the MAPKpk2 gene, a key mediator of inflammatory signaling. Conclusion These results indicate that TNF-α is a physiological regulator of inflammation and macrophage activation induced by scorpion venom.
We previously reported that Androctonus australis hector (Aah) venom and its toxic fraction affect adipose tissue metabolism. However, the contribution of immune system and the role of adipose tissue macrophages (ATMs) in the progression of inflammation induced by scorpion venom remain largely unknown. Here we evaluate the capacity of the toxic fraction of Aah venom (FTox-G50) to induce the expression of M1 and M2 markers genes on adipose tissue and isolated stromal vascular cells (SVC). Quantitative real-time PCR was performed on the SVC 24 h after FTox-G50 venom injection to assess the gene expressions of IL12p40, IL23, and other macrophages-associated markers. We found that ATM from FTox-G50-venom-injected mice markedly increased the expressions of IL-12p40 and IL-23. Furthermore, the expression of nitric oxide synthase 2 (an M1 marker) was up-regulated, but the expression of Arginase1 (an M2 marker) was not. Systemic injection of a chemical inhibitor directed against TNF-α binding reduced the expression of inflammatory M1 macrophage markers and the MAPKpk2 gene, a key mediator of inflammatory signaling. These results indicate that TNF-α is a physiological regulator of inflammation and macrophage activation induced by scorpion venom.
We previously reported that Androctonus australis hector (Aah) venom and its toxic fraction affect adipose tissue metabolism. However, the contribution of immune system and the role of adipose tissue macrophages (ATMs) in the progression of inflammation induced by scorpion venom remain largely unknown. Here we evaluate the capacity of the toxic fraction of Aah venom (FTox-G50) to induce the expression of M1 and M2 markers genes on adipose tissue and isolated stromal vascular cells (SVC). Quantitative real-time PCR was performed on the SVC 24 h after FTox-G50 venom injection to assess the gene expressions of IL12p40, IL23, and other macrophages-associated markers. We found that ATM from FTox-G50-venom-injected mice markedly increased the expressions of IL-12p40 and IL-23. Furthermore, the expression of nitric oxide synthase 2 (an M1 marker) was up-regulated, but the expression of Arginase1 (an M2 marker) was not. Systemic injection of a chemical inhibitor directed against TNF- alpha binding reduced the expression of inflammatory M1 macrophage markers and the MAPKpk2 gene, a key mediator of inflammatory signaling. These results indicate that TNF- alpha is a physiological regulator of inflammation and macrophage activation induced by scorpion venom.
Author Ait-Lounis, Aouatef
Laraba-Djebari, Fatima
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Cites_doi 10.1016/S0041-0101(02)00208-8
10.1016/j.toxicon.2011.08.006
10.1172/JCI27180
10.1111/j.1365-2265.2011.04141.x
10.1038/nri978
10.1172/JCI31561
10.1159/000330241
10.1084/jem.20042028
10.1007/s10753-011-9338-0
10.1172/JCI29881
10.1038/ni.1990
10.1152/ajpendo.00284.2006
10.1038/nri1668
10.1016/j.immuni.2010.05.007
10.1016/j.toxicon.2015.04.007
10.1172/JCI200319451
10.1371/journal.pntd.0001740
10.1371/journal.pone.0106300
10.1371/journal.pone.0088174
10.1073/pnas.1221476110
10.1016/j.toxicon.2011.04.017
10.1016/S1567-5769(02)00115-7
10.1038/nature05894
10.1016/j.intimp.2012.08.009
10.1097/QAD.0b013e32833c323b
10.1016/j.febslet.2005.05.031
10.1371/journal.pone.0066477
10.1155/MI/2006/54273
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Keywords IL12p40
venom
NOSi
TNF- α antagonist
Ftox-G50 venom
IL23
Aah venom
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PublicationSubtitle Official Journal of: The International Association of Inflammation Societies + The European Histamine Research Society
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References Adi-Bessalem, Mendil, Hammoudi-Triki, Laraba-Djebari (CR13) 2012; 35
Zoccal, Bitencourt Cda, Secatto (CR11) 2011; 57
Gordon, Martinez (CR1) 2010; 32
Bronte, Zanovello (CR4) 2005; 5
Gordon (CR5) 2003; 3
Ait-Lounis, Laraba-Djebari (CR14) 2012; 6
Djeraba, Kut, Rasschaert, Quere (CR17) 2002; 2
Petricevich (CR9) 2006; 2006
de Boer, Dikkers, Jurdzinski (CR19) 2014; 9
Krausgruber, Blazek, Smallie (CR26) 2011; 12
Wang, Peters, Kess (CR31) 2006; 116
Lumeng, Bodzin, Saltiel (CR25) 2007; 117
Zoccal, Bitencourt Cda, Paula-Silva (CR12) 2014; 9
Laraba-Djebari, Hammoudi (CR16) 1998; 62
Jalali, Pipelzadeh, Taraz, Khodadadi, Makvandi, Rowan (CR8) 2011; 22
Ishizuka, Ferreira, Grund (CR10) 2012; 14
Cohen, Moscicki, Scott (CR18) 2010; 24
Lumeng, Deyoung, Saltiel (CR30) 2007; 292
Fialho, Maciel, Silva (CR6) 2011; 58
Hevener, Olefsky, Reichart (CR24) 2007; 117
Cohen, Shea, Heffron, Schmelz, Roberts (CR23) 2013; 8
Palm, Medzhitov (CR29) 2013; 110
Bronte, Kasic, Gri (CR28) 2005; 201
Odegaard, Ricardo-Gonzalez, Goforth (CR2) 2007; 447
Park, Lee, Cheon (CR22) 2012; 76
Hadaddezfuli, Khodadadi, Assarehzadegan, Pipelzadeh, Saadi (CR27) 2015; 100
Caspar-Bauguil, Cousin, Galinier (CR21) 2005; 579
Raouraoua-Boukari, Sami-Merah, Hammoudi-Triki, Martin-Eauclaire, Laraba-Djebari (CR15) 2012; 19
Xu, Barnes, Yang (CR20) 2003; 112
Fukuhara, Reis, Dellalibera-Joviliano, Cunha, Donadi (CR7) 2003; 41
Mantovani, Schioppa, Biswas, Marchesi, Allavena, Sica (CR3) 2003; 89
15824085 - J Exp Med. 2005 Apr 18;201(8):1257-68
17200717 - J Clin Invest. 2007 Jan;117(1):175-84
25912944 - Toxicon. 2015 Jun 15;100:27-31
23297192 - Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1809-14
22816003 - PLoS Negl Trop Dis. 2012;6(7):e1740
20510870 - Immunity. 2010 May 28;32(5):593-604
21240265 - Nat Immunol. 2011 Mar;12(3):231-8
12433057 - Int Immunopharmacol. 2002 Oct;2(11):1557-66
17525798 - J Clin Invest. 2007 Jun;117(6):1658-69
21893076 - Toxicon. 2011 Nov;58(6-7):480-5
16886059 - J Clin Invest. 2006 Aug;116(8):2105-14
20588163 - AIDS. 2010 Aug 24;24(13):2069-74
21711372 - Clin Endocrinol (Oxf). 2012 Jan;76(1):59-66
21547500 - Inflammation. 2012 Apr;35(2):501-8
17515919 - Nature. 2007 Jun 28;447(7148):1116-20
21411417 - Eur Cytokine Netw. 2011 Mar;22(1):5-10
14870765 - Tumori. 2003 Sep-Oct;89(5):459-68
22248726 - Neuroimmunomodulation. 2012;19(2):103-10
16056256 - Nat Rev Immunol. 2005 Aug;5(8):641-54
12467661 - Toxicon. 2003 Jan;41(1):49-55
15953605 - FEBS Lett. 2005 Jul 4;579(17):3487-92
23776677 - PLoS One. 2013 Jun 12;8(6):e66477
21549737 - Toxicon. 2011 Jun;57(7-8):1101-8
14679177 - J Clin Invest. 2003 Dec;112(12):1821-30
25233471 - PLoS One. 2014 Sep 18;9(9):e106300
12511873 - Nat Rev Immunol. 2003 Jan;3(1):23-35
16926380 - Am J Physiol Endocrinol Metab. 2007 Jan;292(1):E166-74
11256315 - Arch Inst Pasteur Alger. 1998;62:254-66
22940186 - Int Immunopharmacol. 2012 Dec;14(4):513-22
17392587 - Mediators Inflamm. 2006;2006(6):54273
24516606 - PLoS One. 2014 Feb 07;9(2):e88174
References_xml – volume: 41
  start-page: 49
  year: 2003
  end-page: 55
  ident: CR7
  article-title: Increased plasma levels of IL-1beta, IL-6, IL-8, IL-10 and TNF-alpha in patients moderately or severely envenomed by Tityus serrulatus scorpion sting
  publication-title: Toxicon Off J Int Soc on Toxinol.
  doi: 10.1016/S0041-0101(02)00208-8
  contributor:
    fullname: Donadi
– volume: 58
  start-page: 480
  year: 2011
  end-page: 485
  ident: CR6
  article-title: Immune cells recruitment and activation by Tityus serrulatus scorpion venom
  publication-title: Toxicon Off J Int Soc Toxinol.
  doi: 10.1016/j.toxicon.2011.08.006
  contributor:
    fullname: Silva
– volume: 116
  start-page: 2105
  year: 2006
  end-page: 2114
  ident: CR31
  article-title: Activated macrophages are essential in a murine model for T cell-mediated chronic psoriasiform skin inflammation
  publication-title: J Clin Investig
  doi: 10.1172/JCI27180
  contributor:
    fullname: Kess
– volume: 76
  start-page: 59
  year: 2012
  end-page: 66
  ident: CR22
  article-title: The relationship between fat depot-specific preadipocyte differentiation and metabolic syndrome in obese women
  publication-title: Clin Endocrinol
  doi: 10.1111/j.1365-2265.2011.04141.x
  contributor:
    fullname: Cheon
– volume: 89
  start-page: 459
  year: 2003
  end-page: 468
  ident: CR3
  article-title: Tumor-associated macrophages and dendritic cells as prototypic type II polarized myeloid populations
  publication-title: Tumori.
  contributor:
    fullname: Sica
– volume: 3
  start-page: 23
  year: 2003
  end-page: 35
  ident: CR5
  article-title: Alternative activation of macrophages
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri978
  contributor:
    fullname: Gordon
– volume: 117
  start-page: 1658
  year: 2007
  end-page: 1669
  ident: CR24
  article-title: Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
  publication-title: J Clin Investig
  doi: 10.1172/JCI31561
  contributor:
    fullname: Reichart
– volume: 19
  start-page: 103
  year: 2012
  end-page: 110
  ident: CR15
  article-title: Immunomodulation of the inflammatory response induced by Androctonus australis hector neurotoxins: biomarker interactions
  publication-title: NeuroImmunoModul
  doi: 10.1159/000330241
  contributor:
    fullname: Laraba-Djebari
– volume: 201
  start-page: 1257
  year: 2005
  end-page: 1268
  ident: CR28
  article-title: Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers
  publication-title: J Exp Med
  doi: 10.1084/jem.20042028
  contributor:
    fullname: Gri
– volume: 35
  start-page: 501
  year: 2012
  end-page: 508
  ident: CR13
  article-title: Lung immunoreactivity and airway inflammation: their assessment after scorpion envenomation
  publication-title: Inflammation.
  doi: 10.1007/s10753-011-9338-0
  contributor:
    fullname: Laraba-Djebari
– volume: 117
  start-page: 175
  year: 2007
  end-page: 184
  ident: CR25
  article-title: Obesity induces a phenotypic switch in adipose tissue macrophage polarization
  publication-title: J Clin Investig
  doi: 10.1172/JCI29881
  contributor:
    fullname: Saltiel
– volume: 12
  start-page: 231
  year: 2011
  end-page: 238
  ident: CR26
  article-title: IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses
  publication-title: Nat Immunol
  doi: 10.1038/ni.1990
  contributor:
    fullname: Smallie
– volume: 292
  start-page: E166
  year: 2007
  end-page: E174
  ident: CR30
  article-title: Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins
  publication-title: Am J physiol Endocrinol Metabol.
  doi: 10.1152/ajpendo.00284.2006
  contributor:
    fullname: Saltiel
– volume: 5
  start-page: 641
  year: 2005
  end-page: 654
  ident: CR4
  article-title: Regulation of immune responses by -arginine metabolism
  publication-title: Nat Rev Immunol
  doi: 10.1038/nri1668
  contributor:
    fullname: Zanovello
– volume: 32
  start-page: 593
  year: 2010
  end-page: 604
  ident: CR1
  article-title: Alternative activation of macrophages: mechanism and functions
  publication-title: Immunity
  doi: 10.1016/j.immuni.2010.05.007
  contributor:
    fullname: Martinez
– volume: 100
  start-page: 27
  year: 2015
  end-page: 31
  ident: CR27
  article-title: Hemiscorpius lepturus venom induces expression and production of interleukin-12 in human monocytes
  publication-title: Toxicon Off J Int Soc Toxinol.
  doi: 10.1016/j.toxicon.2015.04.007
  contributor:
    fullname: Saadi
– volume: 22
  start-page: 5
  year: 2011
  end-page: 10
  ident: CR8
  article-title: Serum TNF-alpha levels reflect the clinical severity of envenomation following a Hemiscorpius lepturus sting
  publication-title: Eur Cytokine Netw
  contributor:
    fullname: Rowan
– volume: 112
  start-page: 1821
  year: 2003
  end-page: 1830
  ident: CR20
  article-title: Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
  publication-title: J Clin Investig
  doi: 10.1172/JCI200319451
  contributor:
    fullname: Yang
– volume: 6
  start-page: e1740
  year: 2012
  ident: CR14
  article-title: TNF-alpha involvement in insulin resistance induced by experimental scorpion envenomation
  publication-title: PLoS Negl Tropical Dis.
  doi: 10.1371/journal.pntd.0001740
  contributor:
    fullname: Laraba-Djebari
– volume: 9
  start-page: e106300
  year: 2014
  ident: CR19
  article-title: Mitogen-activated protein kinase-activated protein kinase 2 deficiency reduces insulin sensitivity in high-fat diet-fed mice
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0106300
  contributor:
    fullname: Jurdzinski
– volume: 9
  start-page: e88174
  year: 2014
  ident: CR12
  article-title: TLR2, TLR4 and CD14 recognize venom-associated molecular patterns from Tityus serrulatus to induce macrophage-derived inflammatory mediators
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0088174
  contributor:
    fullname: Paula-Silva
– volume: 110
  start-page: 1809
  year: 2013
  end-page: 1814
  ident: CR29
  article-title: Role of the inflammasome in defense against venoms
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1221476110
  contributor:
    fullname: Medzhitov
– volume: 57
  start-page: 1101
  year: 2011
  end-page: 1108
  ident: CR11
  article-title: Tityus serrulatus venom and toxins Ts1, Ts2 and Ts6 induce macrophage activation and production of immune mediators
  publication-title: Toxicon Off J Int Soc Toxinol.
  doi: 10.1016/j.toxicon.2011.04.017
  contributor:
    fullname: Secatto
– volume: 2
  start-page: 1557
  year: 2002
  end-page: 1566
  ident: CR17
  article-title: Antiviral and antitumoral effects of recombinant chicken myelomonocytic growth factor in virally induced lymphoma
  publication-title: Int Immunopharmacol
  doi: 10.1016/S1567-5769(02)00115-7
  contributor:
    fullname: Quere
– volume: 62
  start-page: 254
  year: 1998
  end-page: 266
  ident: CR16
  article-title: Use of toxic fraction isolated from Algerian Androctonus australis hector scorpion venom for the assessment of anti-venom serum
  publication-title: Archives de l’Institut Pasteur d’Algerie Institut Pasteur d’Algerie.
  contributor:
    fullname: Hammoudi
– volume: 447
  start-page: 1116
  year: 2007
  end-page: 1120
  ident: CR2
  article-title: Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
  publication-title: Nature
  doi: 10.1038/nature05894
  contributor:
    fullname: Goforth
– volume: 14
  start-page: 513
  year: 2012
  end-page: 522
  ident: CR10
  article-title: Role of interplay between IL-4 and IFN-gamma in the in regulating M1 macrophage polarization induced by Nattectin
  publication-title: Int Immunopharmacol
  doi: 10.1016/j.intimp.2012.08.009
  contributor:
    fullname: Grund
– volume: 24
  start-page: 2069
  year: 2010
  end-page: 2074
  ident: CR18
  article-title: Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa
  publication-title: AIDS.
  doi: 10.1097/QAD.0b013e32833c323b
  contributor:
    fullname: Scott
– volume: 579
  start-page: 3487
  year: 2005
  end-page: 3492
  ident: CR21
  article-title: Adipose tissues as an ancestral immune organ: site-specific change in obesity
  publication-title: FEBS Lett
  doi: 10.1016/j.febslet.2005.05.031
  contributor:
    fullname: Galinier
– volume: 8
  start-page: e66477
  year: 2013
  ident: CR23
  article-title: Intra-abdominal fat depots represent distinct immunomodulatory microenvironments: a murine model
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0066477
  contributor:
    fullname: Roberts
– volume: 2006
  start-page: 54273
  year: 2006
  ident: CR9
  article-title: Balance between pro- and anti-inflammatory cytokines in mice treated with Centruroides noxius scorpion venom
  publication-title: Mediators Inflamm
  doi: 10.1155/MI/2006/54273
  contributor:
    fullname: Petricevich
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Snippet Objective We previously reported that Androctonus australis hector (Aah ) venom and its toxic fraction affect adipose tissue metabolism. However, the...
We previously reported that Androctonus australis hector (Aah) venom and its toxic fraction affect adipose tissue metabolism. However, the contribution of...
Objective We previously reported that Androctonus australis hector (Aah) venom and its toxic fraction affect adipose tissue metabolism. However, the...
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SubjectTerms Adipose Tissue - cytology
Adipose Tissue - immunology
Allergology
Androctonus australis
Animals
Biomedical and Life Sciences
Biomedicine
Cytokines - antagonists & inhibitors
Cytokines - genetics
Cytokines - immunology
Dermatology
Etanercept - pharmacology
Gene Expression - drug effects
Immunology
Macrophages - drug effects
Macrophages - immunology
Male
Mice
Neurology
Nitric Oxide Synthase Type II - genetics
Original Research Paper
Pharmacology/Toxicology
Phenotype
Rheumatology
RNA, Messenger - metabolism
Scorpion Venoms - pharmacology
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Title TNF-alpha modulates adipose macrophage polarization to M1 phenotype in response to scorpion venom
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