Does Teriparatide Improve Femoral Neck Fracture Healing: Results From A Randomized Placebo-controlled Trial

• Published in: Clinical orthopaedics and related research Vol. 474; no. 5; pp. 1234 - 1244
• Main Authors: Bhandari, Mohit, Jin, Ling, See, Kyoungah, Burge, Russel, Gilchrist, Nigel, Witvrouw, Richard, Krohn, Kelly D., Warner, Margaret R., Ahmad, Qasim I., Mitlak, Bruce
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2016; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: Aged; Aged, 80 and over; Biomechanical Phenomena; Bone Density Conservation Agents - adverse effects; Bone Density Conservation Agents - therapeutic use; Bone Screws; Clinical Research; Combined Modality Therapy; Conservative Orthopedics; Double-Blind Method; Female; Femoral Neck Fractures - diagnosis; Femoral Neck Fractures - physiopathology; Femoral Neck Fractures - therapy; Femur Neck - diagnostic imaging; Femur Neck - drug effects; Femur Neck - physiopathology; Femur Neck - surgery; Fracture Fixation, Internal - adverse effects; Fracture Fixation, Internal - instrumentation; Fracture Healing - drug effects; Gait; Hip; Humans; Kaplan-Meier Estimate; Male; Medicine; Medicine & Public Health; Middle Aged; Odds Ratio; Orthopedics; Pain Measurement; Pain, Postoperative - etiology; Prospective Studies; Radiography; Recovery of Function; Reoperation; Risk Factors; Sports Medicine; Surgery; Surgical Orthopedics; Teriparatide - adverse effects; Teriparatide - therapeutic use; Time Factors; Treatment Outcome; Fracture Healing; Revision Surgery; Teriparatide; Gait Speed; Internal Fixation

Background There is a medical need for therapies that improve hip fracture healing. Teriparatide (Forteo ® / Forsteo ® , recombinant human parathyroid hormone) is a bone anabolic drug that is approved for treatment of osteoporosis and glucocorticoid-induced osteoporosis in men and postmenopausal wom...