Human Immunodeficiency Virus Type 1 Two-Long Terminal Repeat Circles: A Subject for Debate

• Published in: AIDS reviews Vol. 18; no. 1; p. 23
• Main Authors: Olivares, Isabel, Pernas, María, Casado, Concepción, López-Galindez, Cecilio
• Format: Journal Article
• Language: English
• Published: Spain 01.01.2016
• Subjects: DNA, Circular - analysis; DNA, Circular - genetics; DNA, Viral - analysis; DNA, Viral - genetics; HIV Infections - virology; HIV Long Terminal Repeat - genetics; HIV-1 - genetics; HIV-1 - isolation & purification; Human immunodeficiency virus 1; Humans; Lentivirus; Proviruses - genetics; Proviruses - isolation & purification; Retroviridae; Viral Load; Virus Integration - genetics

HIV-1 infections are characterized by the integration of the reverse transcribed genomic RNA into the host chromosomes making up the provirus. In addition to the integrated proviral DNA, there are other forms of linear and circular unintegrated viral DNA in HIV-1-infected cells. One of these forms,...