Interferon-γ release assay in HIV-infected patients with active tuberculosis: impact of antituberculous drugs on host immune response

• Published in: The New microbiologica Vol. 37; no. 2; pp. 153 - 161
• Main Authors: Sauzullo, Ilaria, Mengoni, Fabio, Ermocida, Angela, Massetti, Anna P, D'Agostino, Claudia, Russo, Gianluca, Salotti, Alessandra, Falciano, Mario, Vullo, Vincenzo, Mastroianni, Claudio M
• Format: Journal Article
• Language: English
• Published: Italy 01.04.2014
• Subjects: Adult; AIDS-Related Opportunistic Infections - diagnosis; AIDS-Related Opportunistic Infections - drug therapy; AIDS-Related Opportunistic Infections - immunology; AIDS-Related Opportunistic Infections - physiopathology; Antitubercular Agents - administration & dosage; Apoptosis - drug effects; Female; Human immunodeficiency virus; Humans; Interferon-gamma - immunology; Interferon-gamma Release Tests - methods; Male; Middle Aged; Mycobacterium; Mycobacterium tuberculosis - drug effects; Mycobacterium tuberculosis - physiology; T-Lymphocytes - cytology; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; Tuberculosis - diagnosis; Tuberculosis - drug therapy; Tuberculosis - immunology; Tuberculosis - physiopathology

The objective of the study was to: 1) investigate the performance of QuantiFERON-TB Gold In-Tube (QFT-GIT) in HIV-infected patients with active tuberculosis (TB); 2) evaluate the sequential changes in QFT-GIT assay during the treatment response; 3) investigate the direct in vitro effects of antitube...