Rechallenge in pediatric patients diagnosed with delayed hypersensitivity to penicillins

beta -Lactams are the most widely used drugs in children but the exact frequency of hypersensitivity reactions to these antibiotics is unknown. Studies based on skin and challenge tests show that allergy is confirmed in 12% to 60% of children with suspected hypersensitivity reactions to beta -lactam...

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Bibliographic Details
Published inJournal of investigational allergology & clinical immunology Vol. 23; no. 5; pp. 369 - 370
Main Authors Berroa, F, Callero, A, Fuentes-Aparicio, V, Infante, S, Alonso-Lebrero, E, Zapatero, L
Format Journal Article
LanguageEnglish
Published Spain 2013
Subjects
Adolescent
Child
Child, Preschool
Drug Hypersensitivity - immunology
Female
Humans
Hypersensitivity, Delayed - immunology
Male
Penicillins - adverse effects
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Summary:beta -Lactams are the most widely used drugs in children but the exact frequency of hypersensitivity reactions to these antibiotics is unknown. Studies based on skin and challenge tests show that allergy is confirmed in 12% to 60% of children with suspected hypersensitivity reactions to beta -lactams [1]. Adverse reactions may be due to different mechanisms. Nonimmediate reactions occur more than 1 hour after drug administration, and most are T-cell mediated [2], The most common manifestation is maculopapular rash. Conventional studies are of little value in the case of delayed reactions [1,2], and the oral challenge test remains the gold standard for confirming or ruling out beta -lactam sensitization. The aim of our study was to reassess tolerance to beta -lactams in children diagnosed with nonimmediate allergy to penicillins after at least 1 year of drug avoidance.
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ISSN:1018-9068