DECREASED BRAINSTEM AND PUTAMEN SERT BINDING POTENTIAL IN DEPRESSED SUICIDE ATTEMPTERS USING [11C]‐ZIENT PET IMAGING

• Published in: Depression and anxiety Vol. 30; no. 10; pp. 902 - 907
• Main Authors: Nye, Jonathon A., Purselle, David, Plisson, Christophe, Voll, Ronald J., Stehouwer, Jeffrey S., Votaw, John R., Kilts, Clinton D., Goodman, Mark M., Nemeroff, Charles B.
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.10.2013
• Subjects: Analysis of Variance; biological markers; Biomarkers - metabolism; Brain; brain imaging/neuroimaging; Brain Mapping - methods; Brain Stem - diagnostic imaging; Brain Stem - metabolism; Case-Control Studies; depression; Depressive Disorder, Major - diagnostic imaging; Depressive Disorder, Major - metabolism; Female; Humans; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging; Male; measurement/psychometrics; Nortropanes; Positron-Emission Tomography - methods; Putamen - diagnostic imaging; Putamen - metabolism; Serotonin Plasma Membrane Transport Proteins - metabolism; Suicide, Attempted; suicide/self‐harm; Suicides & suicide attempts; Young Adult; suicide/self-harm; biological markers; depression; brain imaging/neuroimaging; measurement/psychometrics
• ISSN: 1091-4269; 1520-6394
• DOI: 10.1002/da.22049

Background Deficits in serotonergic neurotransmission have been implicated in the pathogenesis of depression and suicidality. The present study utilized a novel positron‐emission tomography (PET) ligand to quantitate and compare brain regional serotonin transporter (SERT) binding potential in depres...