Abnormal intrinsic brain activity in amnestic mild cognitive impairment revealed by amplitude of low-frequency fluctuation: a resting-state functional magnetic resonance imaging study

• Published in: Chinese medical journal Vol. 126; no. 15; pp. 2912 - 2917
• Main Authors: Xi, Qian, Zhao, Xiao-hu, Wang, Pei-jun, Guo, Qi-hao, He, Yong
• Format: Journal Article
• Language: English
• Published: China Department of Radiology, Tongji Hospital of Tongji University,Shanghai 200065, China%Department of Neurology, Huashan Hospital of Fudan University,Shanghai 200040, China%State Key Laboratory of Cognitive Neuroscience and Learning,Beijing Normal University, Beijing 100875, China 2013
• Subjects: Aged; Alzheimer Disease - physiopathology; Amnesia - physiopathology; Brain - physiopathology; Cognitive Dysfunction - physiopathology; Female; Humans; Magnetic Resonance Imaging; Male; resting-state functional magnetic resonance imaging; amplitude of low-frequency fluctuation; mild cognitive impairment; compensation; Alzheimer's disease

Previous studies have shown that brain functional activity in the resting state is impaired in Alzheimer's disease (AD) patients. However, alterations in intrinsic brain activity patterns in mild cognitive impairment (MCI) patients are poorly understood. This study aimed to explore the differen...