Androgen Receptor (AR) Physiological Roles in Male and Female Reproductive Systems: Lessons Learned from AR-Knockout Mice Lacking AR in Selective Cells

• Published in: Biology of reproduction Vol. 89; no. 1; p. 21
• Main Authors: CHAWNSHANG CHANG, SOO OK LEE, WANG, Ruey-Sheng, SHUYUAN YEH, CHANG, Ta-Min
• Format: Journal Article
• Language: English
• Published: Madison, WI Society for the Study of Reproduction 01.07.2013
• Subjects: Animals; Biological and medical sciences; Female; Fundamental and applied biological sciences. Psychology; Genitalia, Female - physiology; Genitalia, Male - physiology; Male; Mice; Mice, Knockout; Receptors, Androgen - physiology; Vertebrates: reproduction; Androgen; androgens; Spermatogenesis; Rodentia; reproductive system; Male; ARKO mice; sex differentiation; Vertebrata; Reproduction; Mammalia; Mouse; Fertility; Animal; Androgen receptor; Female; Mutation; male sexual function; Sex steroid hormone; Differentiation; androgen receptor; fertility; spermatogenesis

Androgens/androgen receptor (AR) signaling is involved primarily in the development of male-specific phenotypes during embryogenesis, spermatogenesis, sexual behavior, and fertility during adult life. However, this signaling has also been shown to play an important role in development of female repr...