Association of HLA-DR and -DQ genes with narcolepsy in Koreans: comparison with two control groups, randomly selected subjects and DRB11501-DQB10602--positive subjects

• Published in: Human Immunology Vol. 67; no. 9; pp. 749 - 755
• Main Authors: Roh, Eun Youn, Park, Myoung Hee, Park, Hyejin, Park, Doo-Heum, Choi, Jong-Bae, Kim, Seog Ju, Jeong, Do-Un
• Format: Journal Article
• Language: English
• Published: United States 01.09.2006
• Subjects: Adolescent; Adult; Cataplexy - genetics; Child; Female; Gene Frequency; Genetic Predisposition to Disease; HLA-DQ Antigens - genetics; HLA-DR Antigens - genetics; Humans; Korea - epidemiology; Male; Middle Aged; Narcolepsy - genetics; Phenotype; Polymerase Chain Reaction; Korea

The purpose of this study was to investigate the association of human leukocyte antigen (HLA) class II alleles with narcolepsy-cataplexy susceptibility in Koreans. The distribution of HLA-DRB1 and -DQB1 alleles and presence or absence of DRB3/4/5 alleles were examined in 60 narcoleptic patients with...