Voltage-Gated Potassium Currents Are Targets of Diurnal Changes in Estradiol Feedback Regulation and Kisspeptin Action on Gonadotropin-Releasing Hormone Neurons in Mice

• Published in: Biology of reproduction Vol. 85; no. 5; pp. 987 - 995
• Main Authors: PIELECKA-FORTUNA, Justyna, ANTHONY DEFAZIO, R, MOENTER, Suzanne M
• Format: Journal Article
• Language: English
• Published: Madison, WI Society for the Study of Reproduction 01.11.2011
• Subjects: Animals; Biological and medical sciences; Brain - cytology; Circadian Rhythm - physiology; Estradiol - pharmacology; Estradiol - physiology; Feedback, Physiological - physiology; Female; Fundamental and applied biological sciences. Psychology; Gonadotropin-Releasing Hormone - physiology; Green Fluorescent Proteins - genetics; Kisspeptins - pharmacology; Kisspeptins - physiology; Mice; Mice, Transgenic; Models, Animal; Neurons - cytology; Neurons - physiology; Ovariectomy; Patch-Clamp Techniques; Potassium Channels, Voltage-Gated - drug effects; Potassium Channels, Voltage-Gated - physiology; Signal Transduction - physiology; Vertebrates: reproduction; Estrogen; 17β-Estradiol; Gonadotropin RH; Feedback regulation; Ionic channel; Ionic current; Inorganic element; feedback; Reproduction; Hormone releasing factor; CnRH receptor; Biological receptor; estradiol; estradiol receptor; Rodentia; Ovarian hormone; ion channels; Hypothalamic hormone; Kisspeptin; gonadotropin-releasing hormone; Vertebrata; Mammalia; Neuron; Mouse; diurnal; Animal; Sex steroid hormone; Potassium

Estradiol has both negative and positive feedback actions upon gonadotropin-releasing hormone (GnRH) release; the latter actions trigger the preovulatory GnRH surge. Although neurobiological mechanisms of the transitions between feedback modes are becoming better understood, the roles of voltage-gat...