Quantitation of CD55 and CD59 Expression on Reticulocytes and Mature Erythrocytes in Paroxysmal Nocturnal Hemoglobinuria, Aplastic Anemia, and Healthy Control Subjects

• Published in: Annals of clinical and laboratory science Vol. 40; no. 3; pp. 226 - 232
• Main Authors: KIM, Yeongsic, LIM, Jihyang, KIM, Myungshin, KIM, Yonggoo, LEE, Jong-Wook, HAN, Kyungja
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Institute for Clinical Science 01.06.2010
• Subjects: Adult; Anemia, Aplastic - metabolism; Anemias. Hemoglobinopathies; Biological and medical sciences; Case-Control Studies; CD55 Antigens - metabolism; CD59 Antigens - metabolism; Diseases of red blood cells; Erythrocyte Count; Erythrocytes - metabolism; Female; Flow Cytometry; Hematologic and hematopoietic diseases; Hemoglobinuria, Paroxysmal - metabolism; Humans; Immunophenotyping; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Other diseases. Hematologic involvement in other diseases; Reticulocytes - metabolism; Young Adult; Human; Erythrocytic membrane disease; paroxysmal nocturnal hemoglobinuria; Healthy subject; Aplastic anemia; Red blood cell; Biological marker; Hemopathy; Differential diagnostic; Blood cell; Hemolytic anemia; Nocturnal paroxystic anemia; Bone marrow failure; Reticulocyte; CD59; CD55
• ISSN: 0091-7370; 1550-8080; 1550-8080

Since PNH occasionally results in bone marrow failure, it is difficult to differentiate PNH from AA with small numbers of CD(55) (-)CD(59) (-) erythrocytes. We quantified CD55 and CD59 molecules expressed on normal reticulocytes and mature erythrocytes of paroxysmal nocturnal hemoglobinuria (PNH), a...