Expression of Cathepsin-D in Primary Breast Cancer and Corresponding Local Recurrence or Metastasis: An Immunohistochemical Study

• Published in: Anticancer research Vol. 32; no. 3; pp. 901 - 905
• Main Authors: DIAN, D, VREKOUSSIS, T, SHABANI, N, MYLONAS, I, KUHN, C, SCHINDLBECK, C, NAVROZOGLOU, I, FRIESE, K, MAKRIGIANNAKIS, A, JESCHKE, U
• Format: Journal Article
• Language: English
• Published: Attiki International Institute of Anticancer Research 01.03.2012
• Subjects: Biological and medical sciences; Breast Neoplasms - enzymology; Breast Neoplasms - pathology; Cathepsin D - metabolism; Female; Gynecology. Andrology. Obstetrics; Humans; Immunohistochemistry; Mammary gland diseases; Medical sciences; Neoplasm Metastasis; Neoplasm Recurrence, Local; Tumors; Immunohistochemistry; Relapse; Breast disease; Enzyme; Breast cancer; Malignant tumor; Metastasis; Mammary gland diseases; Peptidases; Anatomic pathology; Cancerology; Cathepsin-D; Hydrolases; Aspartic endopeptidases; Cathepsin D; local recurrence; Cancer; Primary cancer

The role of cathepsin-D is well established in breast cancer progression, being correlated with worse clinical outcomes. However, to our knowledge, no study has been performed investigating its expression in primary breast cancer tumors and their corresponding recurrences or metastasis. Tissue secti...