Is More Always Better? Effects of Patch Sampling in Distinguishing Chronic Lymphocytic Leukemia from Transformation to Diffuse Large B-Cell Lymphoma

• Published in: Computational Mathematics Modeling in Cancer Analysis Vol. 13574; pp. 11 - 20
• Main Authors: Bandyopadhyay, Rukhmini, Chen, Pingjun, El Hussein, Siba, Rojas, Frank R., Ebare, Kingsley, Wistuba, Ignacio I., Solis Soto, Luisa M., Medeiros, L. Jeffrey, Zhang, Jianjun, Khoury, Joseph D., Wu, Jia
• Format: Book Chapter
• Language: English
• Published: Switzerland Springer 2022; Springer Nature Switzerland
• Series: Lecture Notes in Computer Science
• Subjects: Accelerated CLL; Chronic Lymphocytic Leukemia (CLL); Patch level analysis; Random sampling; Richter Transformation (RT)

Distinguishing chronic lymphocytic leukemia (CLL), accelerated phase of CLL (aCLL), and diffuse large B-cell lymphoma transformation of CLL (Richter transformation; RT) has important clinical implications that greatly influence patient management. However, distinguishing between these disease phases...