Crystal structure of CC3 (TIP30): implications for its role as a tumor suppressor

• Published in: The Journal of biological chemistry Vol. 280; no. 18; pp. 18229 - 18236
• Main Authors: El Omari, Kamel, Bird, Louise E, Nichols, Charles E, Ren, Jingshan, Stammers, David K
• Format: Journal Article
• Language: English
• Published: United States 06.05.2005
• Subjects: Acetyltransferases - chemistry; Acetyltransferases - metabolism; Acetyltransferases - physiology; Animals; Apoptosis - physiology; Crystallization; Crystallography, X-Ray; Humans; Ligands; Male; Protein Folding; Swine; Transcription Factors - chemistry; Transcription Factors - metabolism; Transcription Factors - physiology; Tumor Suppressor Proteins - chemistry; Tumor Suppressor Proteins - metabolism; Tumor Suppressor Proteins - physiology

CC3 (TIP30) is a protein with pro-apoptotic and anti-metastatic properties. The tumor suppressor effect of CC3 has been suggested to result from inhibition of nuclear transport by binding to importin betas or by regulating transcription through interaction in a complex with co-activator independent...